Jiang Zhihua, Carrion Shane A, Michal Jennifer J, Zhou Xiang, Wang Hongyang, Miller Steve P
Department of Animal Sciences and Center for Reproductive Biology, Washington State University, USA.
Animal Breeding and Genetic Unit, University of New England, Australia.
JSM Sex Med. 2022;6(3). Epub 2022 Aug 2.
Here we propose a new concept called genomunities (genome communities) and thus explore how they govern 116 sexual dimorphism pathways in . Based on alternative polyadenylation events, a total of 262 genomunities were identified to be associated with these pathways. These genomunities originated from six sources: oocytes (maternal RNA), oocytes/zygotes, zygotes, embryos, adult females and adult males. Our discussion is focused on genomunity memberships, genomunity contribution and genomunity partnerships. Overall, our genomunity concept may open new research fronts to understand emerging biological and biomedical questions related to gender and gender expression, sex and gender identity, transgender, gender dysphoria, and sexual orientation, for example.
在此，我们提出了一个名为基因组群落（genomunities，即基因组社区）的新概念，并探索它们如何调控[具体物种]中的116条性别二态性途径。基于可变聚腺苷酸化事件，共鉴定出262个基因组群落与这些途径相关。这些基因组群落源自六个来源：卵母细胞（母源RNA）、卵母细胞/合子、合子、胚胎、成年雌性和成年雄性。我们的讨论集中在基因组群落成员、基因组群落贡献和基因组群落伙伴关系上。总体而言，我们的基因组群落概念可能会开辟新的研究前沿，以理解与性别和性别表达、性与性别认同、跨性别、性别焦虑症以及性取向等相关的新出现的生物学和生物医学问题。
