Chen Xiaodong, Chen Jiawei, Wang Jian, Xu Min, Xue Tao, Zha Dingjun, Chen Fuquan
Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China.
Front Allergy. 2025 May 19;6:1521574. doi: 10.3389/falgy.2025.1521574. eCollection 2025.
To retrospectively summarize the clinical manifestations, pathological characteristics, and efficacy of unilateral allergic fungal rhinosinusitis (AFRS), we analyzed the clinical data of 23 patients diagnosed with unilateral AFRS in a teaching hospital setting. All the patients showed positive reaction for fungal allergens via the skin prick test or serum-specific IgE test. CT scan showed lesions of the sinuses were unilateral. The average postoperative follow-up time was 72 months. Among the cases, 20 cases were cured, and 3 cases were improved. The VAS score decreased from 8.5 preoperatively to 1.1 postoperatively. The eosinophilic mucin, typical CT findings, and fungal-specific type I hypersensitivity are the three clinical features of AFRS. Endoscopic sinus surgery and oral glucocorticoids are effective treatments for AFRS.
为回顾性总结单侧变应性真菌性鼻-鼻窦炎（AFRS）的临床表现、病理特征及疗效，我们分析了一家教学医院中23例诊断为单侧AFRS患者的临床资料。所有患者通过皮肤点刺试验或血清特异性IgE检测对真菌变应原呈阳性反应。CT扫描显示鼻窦病变为单侧。术后平均随访时间为72个月。其中，20例治愈，3例好转。视觉模拟评分（VAS）从术前的8.5降至术后的1.1。嗜酸性黏液、典型CT表现及真菌特异性I型超敏反应是AFRS的三个临床特征。鼻内镜鼻窦手术及口服糖皮质激素是治疗AFRS的有效方法。
