第一人称状态/心理意象调节抑郁症患者的眶额回和壳核。
First person state/psychological imagery modulates the orbital frontal gyrus and the putamen in individuals with depression.
作者信息
Tomasino Barbara, Piani Maria Chiara, Maggioni Eleonora, Bonivento Carolina, D'Agostini Serena, Balestrieri Matteo, Brambilla Paolo
机构信息
Scientific Institute, IRCCS E. Medea, Dipartimento/Unità Operativa Pasian di Prato, Udine, Italy.
Swiss Paraplegic Research, Nottwil, Switzerland.
出版信息
Front Psychiatry. 2025 May 19;16:1583482. doi: 10.3389/fpsyt.2025.1583482. eCollection 2025.
BACKGROUND
Patients with depression appear to imagine scenes preferentially from a 3rd person perspective as if they were observers. Methods: By using functional magnetic resonance imaging we asked patients with major depressive disorder (19, MDD) and healthy controls (19, HC) to imagine 1st person perspective state/psychological (vs. action) scenes.
RESULTS
We found that the left superior frontal gyrus (orbital part) and the right putamen were differentially activated by the state/psychological (vs. action) imagery (vs. letter detection) in MDD individuals vs. HC.
DISCUSSION
We suggest that imagery for state/psychological events increased activation in areas involved in self-related processing and personal perspective changes.
背景
抑郁症患者似乎更倾向于从第三人称视角想象场景，就好像他们是观察者一样。方法：通过功能磁共振成像，我们让重度抑郁症患者（19名，MDD）和健康对照组（19名，HC）想象第一人称视角的状态/心理（与动作相对）场景。
结果
我们发现，与健康对照组相比，重度抑郁症患者中，状态/心理（与动作相对）意象（与字母检测相对）在左侧额上回（眶部）和右侧壳核引起了不同的激活。
讨论
我们认为，状态/心理事件的意象增加了与自我相关处理和个人视角变化相关区域的激活。
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