Yücel Merve, Şengöz Tarık, Şen Türk Nilay
Pamukkale University Faculty of Medicine, Department of Nuclear Medicine, Denizli, Türkiye.
Pamukkale University Faculty of Medicine, Department of Pathology, Denizli, Türkiye.
Mol Imaging Radionucl Ther. 2025 Jun 3;34(2):135-138. doi: 10.4274/mirt.galenos.2024.80388.
Herein, we describe a rare case of multicentric Castleman disease with multiple lymph node and skin involvement. Ultrasonography of a 38-year-old patient with weakness and fever revealed multiple lymphadenopathies in both inguinal regions. Diagnosed via lymph node biopsy was Castleman's disease, a plasma cell variant. He was diagnosed with prurigo nodularis, lymphocytic vasculitis, and stasis dermatitis in the biopsies of skin lesions located in different regions. F-fluorodeoxyglucose positron emission tomography/computed tomography showed multiple hypermetabolic lymph nodes in the axilla, abdomen, pelvis, and both popliteal areas, multiple hypermetabolic skin thickenings, and skin lesions in both arms, legs, and feet.
在此,我们描述了一例罕见的多中心Castleman病,伴有多处淋巴结和皮肤受累。一名38岁伴有乏力和发热的患者,超声检查显示双侧腹股沟区有多处淋巴结病变。经淋巴结活检诊断为Castleman病,即浆细胞变异型。在不同部位的皮肤病变活检中,他被诊断为结节性痒疹、淋巴细胞性血管炎和淤积性皮炎。F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描显示腋窝、腹部、骨盆和双侧腘窝区有多处代谢亢进的淋巴结,双臂、双腿和足部有多处代谢亢进的皮肤增厚及皮肤病变。