Patil Rohit, Arora Sanchit, Kumar Dinesh, Agrawal Ashish Kumar
Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2025 May-Jun;17(3):e70021. doi: 10.1002/wnan.70021.
The rising challenge of antibiotic-resistant bacterial infections poses a severe threat to global health, highlighting the urgent need for innovative treatment strategies. Bacteriophages, viruses specifically targeting and destroying bacteria, have emerged as a promising solution. However, their therapeutic application faces significant hurdles, including sensitivity to the immune system, limited stability, and challenges in effectively reaching infection sites. Multifunctional nanocarriers offer a cutting-edge approach to address these limitations. These nanoscale delivery systems protect bacteriophages from degradation, enhance their stability, and enable precise release at the infection site. Certain nanocarriers are engineered to respond to specific physiological conditions, such as pH or temperature, and can be combined with additional therapies, like antibiotics, for synergistic effects. Moreover, they hold the potential for real-time infection tracking and treatment monitoring, aligning with the goals of personalized medicine. This review highlights the synergistic potential of nanotechnology and bacteriophage therapy in combating antibiotic-resistant bacteria. By overcoming critical barriers to bacteriophage application, multifunctional nanocarriers represent a transformative advancement in the fight against drug-resistant infections. Furthermore, their ability to enhance treatment efficacy and outcomes establishes them as an essential innovation in advancing global health solutions.
抗生素耐药性细菌感染带来的挑战日益严峻，对全球健康构成了严重威胁，凸显出对创新治疗策略的迫切需求。噬菌体，即专门靶向并破坏细菌的病毒，已成为一种颇具前景的解决方案。然而，它们的治疗应用面临着重大障碍，包括对免疫系统敏感、稳定性有限以及有效抵达感染部位的挑战。多功能纳米载体提供了一种前沿方法来克服这些限制。这些纳米级递送系统可保护噬菌体不被降解，增强其稳定性，并使其能够在感染部位精确释放。某些纳米载体经过设计，可对特定生理条件（如pH值或温度）做出反应，并且可以与其他疗法（如抗生素）联合使用，以产生协同效应。此外，它们具有实时感染追踪和治疗监测的潜力，符合个性化医疗的目标。本综述强调了纳米技术与噬菌体疗法在对抗抗生素耐药细菌方面的协同潜力。通过克服噬菌体应用的关键障碍，多功能纳米载体代表了对抗耐药感染的变革性进展。此外，它们提高治疗效果和结果的能力使其成为推进全球健康解决方案的一项重要创新。
