Zhou Xiaojun, Ding Huan, Wang Bin, Kang Hui
Department of Pain Medicine, Hubei NO.3 People's Hospital of Jianghan University, Wuhan, 430033, China.
Department of Blood Transfusion, Hubei NO.3 People's Hospital of Jianghan University, Wuhan, 430033, China.
J Neurovirol. 2025 Jun 3. doi: 10.1007/s13365-025-01264-9.
Postherpetic neuralgia (PHN) represents the most prevalent and distressing complication of shingles. The aim of this study was to explore the diagnostic significance of miR-34c-5p in PHN patients and to assess its correlation with rehabilitation effect.
This study enrolled 154 PHN patients and 108 healthy participants as research subjects. RT-qPCR was used to detect serum miR-34c-5p levels in the participants. ROC curve was employed to estimate the diagnostic significance of miR-34c-5p in PHN patients. Logistic regression analysis was performed to analyze the risk factors related to the occurrence of PHN. VAS, TEX-Q and HADS scales were filled in by questionnaires to analyze the rehabilitation effect of PHN patients after treatment. Spearman correlation analysis was applied to evaluate the relationship of miR-34c-5p levels with rehabilitation effect in treated PHN patients.
miR-34c-5p levels were notably elevated in PHN patients compared to healthy participants. miR-34c-5 had a high sensitivity (79.2%) and specificity (84.3%) to distinguish between healthy individuals and PHN patients. Logistic regression analysis indicated that miR-34c-5p emerged as an independent risk factor for the development of PHN. miR-34c-5p levels, VAS, TEX-Q, HADS-A and HADS-D scores were reduced in prednisone-treated PHN patients compared to the basic treatment group. In addition, Spearman correlation suggested that miR-34c-5p levels were positively correlated with VAS, TEX-Q, HADS-A and HADS-D scores.
miR-34c-5p exhibited the ability to diagnose PHN and may be a biomarker for diagnosis of this disease. Moreover, reduced miR-34c-5p expression in PHN patients correlate with enhanced outcomes in rehabilitation.
带状疱疹后神经痛（PHN）是带状疱疹最常见且令人痛苦的并发症。本研究旨在探讨miR-34c-5p在PHN患者中的诊断意义，并评估其与康复效果的相关性。
本研究纳入154例PHN患者和108名健康参与者作为研究对象。采用RT-qPCR检测参与者血清miR-34c-5p水平。利用ROC曲线评估miR-34c-5p在PHN患者中的诊断意义。进行逻辑回归分析以分析与PHN发生相关的危险因素。通过问卷调查填写VAS、TEX-Q和HADS量表，以分析PHN患者治疗后的康复效果。应用Spearman相关性分析评估治疗后PHN患者中miR-34c-5p水平与康复效果的关系。
与健康参与者相比，PHN患者的miR-34c-5p水平显著升高。miR-34c-5在区分健康个体和PHN患者方面具有较高的敏感性（79.2%）和特异性（84.3%）。逻辑回归分析表明，miR-34c-5p是PHN发生的独立危险因素。与基础治疗组相比，泼尼松治疗的PHN患者的miR-34c-5p水平、VAS、TEX-Q、HADS-A和HADS-D评分均降低。此外，Spearman相关性分析表明，miR-34c-5p水平与VAS、TEX-Q、HADS-A和HADS-D评分呈正相关。
miR-34c-5p具有诊断PHN的能力，可能是该疾病诊断的生物标志物。此外，PHN患者中miR-34c-5p表达降低与康复效果改善相关。
