Wang Mengjiao, Liu Yansong, Han Wei, Yang Yifeng, Jiao Yuying, Hu Yujie, Yang Yang, Zhang Linhan, Wang Yangyang, Fu Peng, Zhao Changjiu
Department of Nuclear Medicine, 1 st Hospital of Harbin Medical University, 23 Post Street, Harbin, 15000, Heilongjiang Province, China.
Department of Endocrinology, Heilongjiang Provincial Second Hospital, Harbin, China.
Brain Imaging Behav. 2025 Aug;19(4):938-948. doi: 10.1007/s11682-025-01023-8. Epub 2025 Jun 3.
This study aimed to use simultaneous F-FDG PET/MRI based on Automated Fiber Quantification (AFQ) to determine whether there is a relationship between white matter microstructure changes and glucose metabolism distribution in PD. The study involved 38 subjects, including 23 parkinson's disease (PD) patients and 15 age and sex-matched healthy controls (HC). Primary clinical data and cognitive assessments were collected. All subjects underwent a simultaneous F-FDG PET/MRI scan. AFQ was utilized to calculate tract-wise diffusion properties of 20 major white matter tracts. PD patients showed reduced mean Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores compared to HC subjects (P < 0.05). PD patients showed higher mean diffusivity (MD) (P = 0.047) and axial diffusivity (AD) (P = 0.02) along the right corticospinal tract (CST) compared to HC. The microstructural change of CST was mainly located in the parietal part (node 67-100). Compared to HC, PD patients had FDG hypermetabolism in the right paracentral lobule (P = 0.0204) and bilateral putamen (left: P = 0.0075; right: P = 0.0155) and hypometabolism in the right calcarine (P = 0.0489). Hypermetabolism was found in the right paracentral lobule, which connects with the cortex of the right CST, and positively correlated with MD (r = 0.612, P < 0.001) and AD (r = 0.516, P < 0.001). We observed microstructural changes and glucose metabolism distribution characteristics in PD patients. These results may provide imaging evidence for studying the pathology of PD.
本研究旨在基于自动纤维定量（AFQ）技术，利用同步F-FDG PET/MRI来确定帕金森病（PD）患者白质微观结构变化与葡萄糖代谢分布之间是否存在关联。该研究纳入了38名受试者，其中包括23名帕金森病（PD）患者以及15名年龄和性别匹配的健康对照者（HC）。收集了主要临床数据和认知评估结果。所有受试者均接受了同步F-FDG PET/MRI扫描。利用AFQ计算20条主要白质束的逐束扩散特性。与HC受试者相比，PD患者的简易精神状态检查表（MMSE）和蒙特利尔认知评估量表（MoCA）平均得分降低（P < 0.05）。与HC相比，PD患者右侧皮质脊髓束（CST）的平均扩散率（MD）（P = 0.047）和轴向扩散率（AD）（P = 0.02）更高。CST的微观结构变化主要位于顶叶部分（节点67 - 100）。与HC相比，PD患者右侧中央旁小叶（P = 0.0204）和双侧壳核（左侧：P = 0.0075；右侧：P = 0.0155）存在FDG高代谢，而右侧距状裂存在低代谢（P = 0.0489）。在与右侧CST皮质相连的右侧中央旁小叶发现高代谢，且与MD（r = 0.612，P < 0.001）和AD（r = 0.516，P < 0.001）呈正相关。我们观察到了PD患者的微观结构变化和葡萄糖代谢分布特征。这些结果可能为研究PD的病理学提供影像学证据。
