Agarwal Anurag, Sajlan Shweta, Chawla Rohit, Mathur Surendra Bahadur
Department of Pediatrics, Maulana Azad Medical College & Associated Hospitals, Bahadur Shah Zafar Marg, New Delhi, 110002, India.
Department of Microbiology, Maulana Azad Medical College & Associated Hospitals, Bahadur Shah Zafar Marg, New Delhi, 110002, India.
Indian Pediatr. 2025 Jun 3. doi: 10.1007/s13312-025-00090-w.
To determine the seroprevalence of hepatitis A among non-vaccinated adolescents aged 9-12 years and to ascertain the sociodemographic factors associated with seropositivity.
A cross-sectional study was conducted among non-vaccinated adolescents aged 9-12 years from urban and semi-urban settings in New Delhi. Sera were analyzed using competitive ELISA to detect IgG antibodies against hepatitis A. Sociodemographic data were collected using a structured pro forma.
Of the 94 participants, 85 (90.4%) were seropositive for hepatitis A. Seropositivity was significantly associated with low socioeconomic status, lower parental education levels, lower parental occupation status, and low monthly household income.
Despite improved sanitation, lower socioeconomic groups remain highly endemic for hepatitis A. Catch-up vaccination may have limited utility in adolescents aged 10 years or older from these backgrounds. Targeted public health strategies and further evaluation of vaccination policies in specific populations are needed.
Clinical Trials Registry-India No. CTRI/2022/10/046790.Obtained.
确定9至12岁未接种疫苗青少年中甲型肝炎的血清流行率，并确定与血清阳性相关的社会人口学因素。
在新德里城市和半城市地区对9至12岁未接种疫苗的青少年进行了一项横断面研究。使用竞争性酶联免疫吸附测定法分析血清，以检测抗甲型肝炎IgG抗体。使用结构化表格收集社会人口学数据。
在94名参与者中，85名（90.4%）甲型肝炎血清呈阳性。血清阳性与社会经济地位低、父母教育水平较低、父母职业地位较低以及家庭月收入低显著相关。
尽管卫生条件有所改善，但社会经济地位较低的群体仍然是甲型肝炎的高流行区。对于来自这些背景的10岁及以上青少年，补种疫苗的作用可能有限。需要有针对性的公共卫生策略，并对特定人群的疫苗接种政策进行进一步评估。
印度临床试验注册中心编号CTRI/2022/10/046790。已获得。
