印度新德里9至12岁未接种疫苗青少年甲型肝炎血清流行率：一项横断面研究。

Seroprevalence of Hepatitis A in Non-vaccinated Adolescents Aged 9 to 12 Years in New Delhi, India: A Cross-Sectional Study.

作者信息

Agarwal Anurag, Sajlan Shweta, Chawla Rohit, Mathur Surendra Bahadur

机构信息

Department of Pediatrics, Maulana Azad Medical College & Associated Hospitals, Bahadur Shah Zafar Marg, New Delhi, 110002, India.

Department of Microbiology, Maulana Azad Medical College & Associated Hospitals, Bahadur Shah Zafar Marg, New Delhi, 110002, India.

出版信息

Indian Pediatr. 2025 Jun 3. doi: 10.1007/s13312-025-00090-w.

DOI:10.1007/s13312-025-00090-w

PMID:40459807

Abstract

OBJECTIVE

To determine the seroprevalence of hepatitis A among non-vaccinated adolescents aged 9-12 years and to ascertain the sociodemographic factors associated with seropositivity.

METHODS

A cross-sectional study was conducted among non-vaccinated adolescents aged 9-12 years from urban and semi-urban settings in New Delhi. Sera were analyzed using competitive ELISA to detect IgG antibodies against hepatitis A. Sociodemographic data were collected using a structured pro forma.

RESULTS

Of the 94 participants, 85 (90.4%) were seropositive for hepatitis A. Seropositivity was significantly associated with low socioeconomic status, lower parental education levels, lower parental occupation status, and low monthly household income.

CONCLUSIONS

Despite improved sanitation, lower socioeconomic groups remain highly endemic for hepatitis A. Catch-up vaccination may have limited utility in adolescents aged 10 years or older from these backgrounds. Targeted public health strategies and further evaluation of vaccination policies in specific populations are needed.