He Tianming, Liu Yang, Yang Zheng, Zhai Shaobo, Wu Yuchuan, Shi Xiaolu, Chu Shunli
Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun 130012, China.
ACS Biomater Sci Eng. 2025 Jul 14;11(7):3875-3892. doi: 10.1021/acsbiomaterials.5c00248. Epub 2025 Jun 3.
Microalgae robots are an emerging biohybrid microrobot that combines the biological properties of microalgae with microrobot technology and shows a wide range of applications in the medical field. In recent years, it has been found that microalgae are ideal biodriven carriers as they have good binding sites and unique properties such as motility, light responsiveness, and oxygen production. The natural substances inside microalgae also have certain medical value and can act synergistically with the exogenous drugs carried. This study provides an in-depth summary of the progress of research and application of microalgae robots in biomedicine over the past 3 years, with a view of providing new ideas for the fabrication and medical application of microalgae robots. This review first introduces the structure and properties of microalgae, which is the basis for the design of microalgae robots; second, it summarizes the formation and movement of microalgae robots, which are formed by functionalizing the surface of microalgae to form microalgae robots with various functions and driven to move in a directional manner by their own targeting ability and external means; the last and most important is it introduces the current research status of microalgae robot applications in drug delivery, targeted treatment of tumors and gastrointestinal inflammation, medical imaging, tissue regeneration, and other fields, as well as their advantages in terms of environmental friendliness, and the future prospects of microalgae robots in the field of biomedicine are also demonstrated.
微藻机器人是一种新兴的生物杂交微机器人，它将微藻的生物学特性与微机器人技术相结合，在医学领域展现出广泛的应用前景。近年来，人们发现微藻是理想的生物驱动载体，因为它们具有良好的结合位点以及诸如运动性、光响应性和产氧等独特特性。微藻内部的天然物质也具有一定的医学价值，并且能够与所携带的外源药物协同发挥作用。本研究深入总结了微藻机器人在过去3年里在生物医学领域的研究与应用进展，以期为微藻机器人的制造和医学应用提供新思路。这篇综述首先介绍了微藻的结构和特性，这是设计微藻机器人的基础；其次，总结了微藻机器人的形成和运动方式，微藻机器人是通过对微藻表面进行功能化处理而形成具有各种功能的微藻机器人，并借助自身的靶向能力和外部手段实现定向移动；最后也是最重要的，介绍了微藻机器人在药物递送、肿瘤和胃肠道炎症的靶向治疗、医学成像、组织再生等领域的应用现状，以及它们在环境友好性方面的优势，同时还展示了微藻机器人在生物医学领域的未来前景。
