Rettenmaier M A, Senyei A E, Widder K J, Stratton J A, Berman M L, Disaia P J
J Clin Lab Immunol. 1985 Jun;17(2):99-103.
The effect of non-localized magnetically responsive albumin microspheres (MR-AMS) on RES phagocytic function was investigated. MR-AMS and MR-AMS containing Adriamycin (MR-AMS-ADR) were injected intravenously in rats at a dose which saturated all RES phagocytes. The ability of the RES to clear the bloodstream of a subsequent suspension of MR-AMS or streptococci was then analyzed over a three day period. MR-AMS clearance was enhanced after initial RES saturation with MR-AMS but depressed when the saturating agent was MR-AMS-ADR. Bloodstream clearance of streptococci was depressed by MR-AMS and MR-AMS-ADR. Localization of MR-AMS in the RES might depress RES phagocytosis by physical saturation of phagocytes or by a direct toxic effect of encapsulated chemotherapeutic agents.
研究了非定位性磁响应白蛋白微球（MR-AMS）对网状内皮系统（RES）吞噬功能的影响。将MR-AMS和含阿霉素的MR-AMS（MR-AMS-ADR）以饱和所有RES吞噬细胞的剂量静脉注射到大鼠体内。然后在三天的时间内分析RES清除随后注入的MR-AMS或链球菌悬液的能力。在用MR-AMS使RES初始饱和后，MR-AMS的清除增强，但当饱和剂为MR-AMS-ADR时清除降低。MR-AMS和MR-AMS-ADR均可降低链球菌的血流清除率。RES中MR-AMS的定位可能通过吞噬细胞的物理饱和或包封化疗药物的直接毒性作用而抑制RES吞噬作用。
