He Wei, You Zhixin, Li Huijiao, Wang Yiping, Li Guohua
Department of Respiratory, Shaoxing Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Shaoxing, Zhejiang, China.
PLoS One. 2025 Jun 3;20(6):e0325150. doi: 10.1371/journal.pone.0325150. eCollection 2025.
This meta-analysis investigates the differential risks of suicidal behaviors (ideation, attempts, mortality) associated with current asthma and asthma history.
Retrieve cohort studies on the association between asthma and suicide from PubMed, Embase, and Cochrane library database. Use the Newcastle Ottawa Quality Assessment Scale (NOS) to assess the risk of bias. The risk ratio (RR) of 95% confidence interval (CI) was summarized using a random effects model, and publication bias was evaluated using funnel plots and Egger's trials.
A total of 12 cohort studies were included and published between 2005 and 2024. The NOS scores for the 12 cohort studies included in this meta-analysis ranged from 7 to 9. Most studies received scores of 7 or 8, indicating a generally high quality. Current asthma conferred a 62% increased risk of suicidal behaviors (RR = 1.62, 95% CI: 1.38-1.88), with suicide attempts showing the strongest association (RR = 2.27, 95% CI: 1.33-3.89). Asthma history was linked only to elevated suicide mortality (RR = 1.87, 95% CI: 1.64-2.14), not non-fatal suicidal behaviors.
Current asthma status is associated with an increased risk of suicidal behaviors, but a history of asthma correlates only with elevated suicide mortality. This finding highlights the need for proactive mental health screening in asthma management protocols, especially during periods of active disease.
本荟萃分析旨在研究当前哮喘及哮喘病史与自杀行为（意念、未遂、死亡）之间的差异风险。
从PubMed、Embase和Cochrane图书馆数据库中检索关于哮喘与自杀关联的队列研究。使用纽卡斯尔渥太华质量评估量表（NOS）评估偏倚风险。采用随机效应模型汇总95%置信区间（CI）的风险比（RR），并使用漏斗图和Egger检验评估发表偏倚。
共纳入2005年至2024年期间发表的12项队列研究。本荟萃分析纳入的12项队列研究的NOS评分范围为7至9分。大多数研究得分为7或8分，表明质量总体较高。当前哮喘使自杀行为风险增加62%（RR = 1.62，95% CI：1.38 - 1.88），其中自杀未遂的关联性最强（RR = 2.27，95% CI：1.33 - 3.89）。哮喘病史仅与自杀死亡率升高有关（RR = 1.87，95% CI：1.64 - 2.14），与非致命自杀行为无关。
当前哮喘状态与自杀行为风险增加有关，但哮喘病史仅与自杀死亡率升高相关。这一发现凸显了在哮喘管理方案中进行积极心理健康筛查的必要性，尤其是在疾病活动期。
