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急性创伤模型中经皮气管切开术与气管内通气的比较。

A comparison of PTV and endotracheal ventilation in an acute trauma model.

作者信息

Jorden R C, Moore E E, Marx J A, Honigman B

出版信息

J Trauma. 1985 Oct;25(10):978-83. doi: 10.1097/00005373-198510000-00009.

DOI:10.1097/00005373-198510000-00009
PMID:4046087
Abstract

Percutaneous transtracheal ventilation (PTV) is an active airway management technique that may be an alternative to cricothyroidotomy in critically injured patients. A canine trauma model was devised to compare the ventilatory capacity and hemodynamic effects of PTV to endotracheal intubation. Mongrel dogs (25-37 kg), splenectomized 14 days previously, were anesthetized with pentobarbital and bled to a mean arterial pressure (MAP) of 20 mm Hg. Animals were maintained at this MAP for 1 hour, then resuscitated with simultaneous: a) aortic crossclamping via left thoracotomy, b) Ringer's lactate infusion, and c) active airway support. Control animals (N = 5), intubated with a cuffed endotracheal tube, were ventilated at a rate of 12 per minute, a tidal volume of 500 cc and an FIO2 of 60%. In study animals (N = 5), PTV, for a duration of 1 second, was instituted at the same rate and FIO2. There was no statistically significant difference between the two groups with regard to pO2, pCO2, pH, and hemodynamic parameters. PTV was also performed in the emergency department on four patients unresponsive to resuscitative thoracotomy for postinjury cardiac arrest. PTV rate was 12/minute; duration, 1 second; and FIO2, 100%. Mean values (+/- SEM) for pH, pO2, and pCO2 obtained after 15 minutes of PTV were 7.14 +/- 0.03, 322 +/- 49.5 torr, and 21.5 +/- 4.7 torr, respectively. PTV is comparable to endotracheal intubation with respect to oxygenation, ventilation and hemodynamic response (p greater than 0.05). Our preliminary clinical study corroborates its efficacy in the acute trauma setting and supports further clinical investigation.

摘要

经皮气管通气(PTV)是一种主动气道管理技术,对于重伤患者而言,它可能是环甲膜切开术的一种替代方法。设计了一种犬类创伤模型,以比较PTV与气管插管的通气能力和血流动力学效应。选用14天前已行脾切除术的杂种犬(体重25 - 37千克),用戊巴比妥麻醉,放血使平均动脉压(MAP)降至20毫米汞柱。动物维持此MAP 1小时,然后同时进行复苏:a)经左胸切开术进行主动脉交叉钳夹,b)输注乳酸林格液,c)主动气道支持。对照组动物(N = 5),插入带气囊的气管导管,以每分钟12次的频率、500立方厘米的潮气量和60%的吸入氧浓度进行通气。研究组动物(N = 5),以相同的频率和吸入氧浓度进行持续1秒的PTV。两组在动脉血氧分压、二氧化碳分压、pH值和血流动力学参数方面无统计学显著差异。在急诊科,还对4例因伤后心脏骤停而对复苏性开胸手术无反应的患者进行了PTV。PTV频率为每分钟12次;持续时间为1秒;吸入氧浓度为100%。PTV 15分钟后测得的pH值、动脉血氧分压和二氧化碳分压的平均值(±标准误)分别为7.14±0.03、322±49.5托和21.5±4.7托。在氧合、通气和血流动力学反应方面,PTV与气管插管相当(p>0.05)。我们的初步临床研究证实了其在急性创伤情况下的有效性,并支持进一步的临床研究。

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