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在呼吸暂停后绵羊的气道阻塞模型中进行经皮气管通气

Percutaneous transtracheal ventilation in an obstructed airway model in post-apnoeic sheep.

作者信息

Berry M, Tzeng Y, Marsland C

机构信息

Centre for Translational Physiology, University of Otago, Wellington, New Zealand Department of Paediatrics and Child Health, University of Otago, Wellington, New Zealand.

Centre for Translational Physiology, University of Otago, Wellington, New Zealand Department of Surgery and Anaesthesia, University of Otago, Wellington, New Zealand.

出版信息

Br J Anaesth. 2014 Dec;113(6):1039-45. doi: 10.1093/bja/aeu188. Epub 2014 Jun 30.

Abstract

BACKGROUND

Temporizing oxygenation by percutaneous transtracheal ventilation (PTV) is a recommended emergency technique in 'can't intubate, can't oxygenate' (CICO) situations. Barotrauma risk increases if expiration is obstructed. The Ventrain(®) is a new PTV device that assists expiration. Our aim was to compare key physiological outcomes after PTV with the Ventrain and the Manujet(®) in a large animal obstructed airway model.

METHODS

Five anaesthetized sheep had post-apnoea PTV performed for 15 min using the Ventrain or Manujet with the proximal airway completely or critically obstructed, yielding four ventilation protocols per sheep. After apnoeic desaturation ([Formula: see text]70%), a 4 s rescue breath was delivered. Subsequent 2 s breaths were delivered whenever the airway pressure fell <10 cm H2O.

RESULTS

Both devices achieved rapid re-oxygenation. There were marked device differences (Ventrain vs Manujet) in peak airway pressures with rescue (16 vs 40 cm H2O) breaths, minute ventilation (4.7 vs 0.1 litre min(-1)), and end-protocol pH (7.34 vs 7.01). There was no clinical evidence of barotrauma in any sheep after any ventilation protocol. An equilibration phase prevented large subatmospheric intrathoracic pressure development with Ventrain ventilation.

CONCLUSIONS

The Ventrain provided stable oxygenation and effective ventilation at low airway pressures during emergency PTV in critically obstructed airways. The Manujet provided effective temporizing oxygenation in this situation with hypoventilation necessary to minimize barotrauma risk. The nature and extent of airway obstruction may not be known in a CICO emergency but an understanding of device differences may help inform optimal ventilation device and method selection.

摘要

背景

在“无法插管、无法给氧”(CICO)的情况下,经皮气管通气(PTV)进行临时给氧是一项推荐的急救技术。如果呼气受阻,气压伤风险会增加。Ventrain(®)是一种新型的PTV设备,可辅助呼气。我们的目的是在大型动物气道阻塞模型中比较使用Ventrain和Manujet(®)进行PTV后的关键生理指标。

方法

对五只麻醉的绵羊进行呼吸暂停后的PTV,使用Ventrain或Manujet,近端气道完全或严重阻塞,每只绵羊产生四种通气方案。在呼吸暂停性低氧血症([公式:见正文]<70%)后,给予4秒的抢救呼吸。每当气道压力降至<10 cm H2O时,随后给予2秒的呼吸。

结果

两种设备均实现了快速复氧。在抢救呼吸时的峰值气道压力(16 vs 40 cm H2O)、分钟通气量(4.7 vs 0.1升·分钟-1)和实验结束时的pH值(7.34 vs 7.01)方面,两种设备存在显著差异(Ventrain与Manujet)。在任何通气方案后,任何绵羊均无气压伤的临床证据。一个平衡期可防止Ventrain通气时出现大的胸内负压。

结论

在严重阻塞气道的紧急PTV过程中,Ventrain在低气道压力下提供了稳定的氧合和有效的通气。在这种情况下,Manujet提供了有效的临时氧合,但需要低通气以尽量降低气压伤风险。在CICO紧急情况下,气道阻塞的性质和程度可能未知,但了解设备差异可能有助于指导最佳通气设备和方法的选择。

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