Camara Célia F, Filippetti Maria Laura, Sel Alejandra
Department of Psychology, University of Essex, Colchester, UK.
Proc Biol Sci. 2025 Jun;292(2048):20242625. doi: 10.1098/rspb.2024.2625. Epub 2025 Jun 4.
Bodily organs such as the heart and the lungs play a crucial role in maintaining physiological homeostasis in a continuous closed-loop interaction with the brain. Beyond their vital role, recent developments have emphasized the remarkable contribution of bodily signals to high-level brain functions. A direct route by which bodily signals influence brain functioning is via modulation of electrophysiological dynamics, which in turn influences the integration and processing of emotional and self-related information regulating our conscious experience. Drawing on electrophysiological investigations, we provide a comprehensive picture of the electrophysiology of interoception and its contribution to emotion, self and bodily consciousness, with a focus on cardiac, respiratory and gastric interoception. We provide evidence that altered neurophysiological responses in interoception might underlie deficits in psychopathology. We also summarize the limited evidence on the development of the electrophysiology of interoception during infancy and adolescence, as well as describing some attempts to investigate causality in the neural mechanisms underpinning interoception. A number of important areas for further research are highlighted.
诸如心脏和肺等身体器官在与大脑持续的闭环相互作用中，对维持生理稳态起着至关重要的作用。除了其重要作用外，最近的进展强调了身体信号对高级脑功能的显著贡献。身体信号影响大脑功能的一条直接途径是通过调节电生理动力学，这反过来又影响调节我们意识体验的情绪和自我相关信息的整合与处理。基于电生理研究，我们全面阐述了内感受的电生理学及其对情绪、自我和身体意识的贡献，重点关注心脏、呼吸和胃部内感受。我们提供证据表明，内感受中神经生理反应的改变可能是精神病理学缺陷的基础。我们还总结了关于婴儿期和青少年期内感受电生理学发展的有限证据，并描述了一些在支撑内感受的神经机制中研究因果关系的尝试。突出了一些有待进一步研究的重要领域。
