Cesari Matteo, Brink-Kjaer Andreas, During Emmanuel, Ganglberger Wolfgang, Gnarra Oriella, Huang Bei, Sommerauer Michael, Ratti Pietro Luca, Rechichi Irene, Wing Yun Kwok, Stefani Ambra
Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Department of Health Technology, Technical University of Denmark, Kgs. Lyngby, Denmark.
J Sleep Res. 2025 Oct;34(5):e70109. doi: 10.1111/jsr.70109. Epub 2025 Jun 3.
Rapid eye movement (REM) sleep behaviour disorder (RBD) is a parasomnia characterised by the loss of muscle atonia during REM sleep and dream-enacting behaviours. In its isolated form (iRBD) it is widely recognised as an early stage of alpha-synucleinopathies. Early identification of patients with iRBD allows for timely interventions, risk mitigation and potential inclusion in clinical trials aimed at disease modification. Effective screening tools, including questionnaires, automatic analyses of video-polysomnography, actigraphy, nearables and biological markers, can facilitate diagnosis and monitoring. Incorporating routine screening into clinical practice may enhance early detection and improve long-term patient outcomes. This manuscript presents the latest developments in screening tools for the identification of patients with iRBD and discusses their advantages and drawbacks, highlighting paths for future research and applications.
快速眼动（REM）睡眠行为障碍（RBD）是一种异态睡眠，其特征是在快速眼动睡眠期间肌肉张力缺失以及出现梦境扮演行为。以孤立形式存在的RBD（iRBD）被广泛认为是α-突触核蛋白病的早期阶段。对iRBD患者进行早期识别有助于及时进行干预、降低风险，并有可能纳入旨在改变疾病进程的临床试验。有效的筛查工具，包括问卷、视频多导睡眠图自动分析、活动记录仪、近场可穿戴设备和生物标志物，可促进诊断和监测。将常规筛查纳入临床实践可能会提高早期检测率并改善患者的长期预后。本文介绍了用于识别iRBD患者的筛查工具的最新进展，并讨论了它们的优缺点，突出了未来研究和应用的方向。
