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通过分形分数算子对修正后的血糖胰岛素模型进行数学分析。

Mathematical analysis of modified blood glucose insulin model through fractal fractional operators.

作者信息

Gassem F, Zahir Abrar, Dawood Arafa, Almalahi Mohammed, Ali Amjad, Aldwoah Khaled

机构信息

Department of Mathematics, University of Ha'il, 55473, Ha'il, Saudi Arabia.

Department of Mathematics and Statistics, University of Swat, Khyber Pakhtunkhwa, Pakistan.

出版信息

Sci Rep. 2025 Jun 3;15(1):19452. doi: 10.1038/s41598-025-04416-3.

Abstract

This study presents an advanced mathematical perspective of a generalized diabetes model, emphasizing the critical complications associated with this disease, such as cardiovascular disease, kidney failure, nerve damage, vision problems, and weakened immunity conditions, which can escalate into life-threatening conditions such as heart attacks, strokes, and blindness. Blood glucose, an essential energy source for the human body, is regulated by hormones such as insulin and glucagon. Diabetes emerges either due to the body's resistance to insulin or the autoimmune destruction of insulin-producing cells in the pancreas. Focusing on these physiological insights, we reformulate the blood glucose-insulin (MBGI) model by incorporating some novel parameters, introducing a dietary intake compartment, and employing a new fractional operator in the sense of a fractal-fractional derivative to better capture the complex dynamics of the disease. This study investigates the existence, uniqueness, and Hyers-Ulam stability of solutions via fixed-point approaches, particularly Leray-Schauder techniques. Furthermore, a numerical scheme based on Newton's polynomial interpolation is developed to visualize the behavior of the model. The attained results show that increasing both the fractal dimension and fractional order leads to a crucial reduction in glucose concentration, offering valuable insights for the effective management and control of diabetes.

摘要

本研究提出了一种广义糖尿病模型的先进数学视角,强调了与该疾病相关的关键并发症,如心血管疾病、肾衰竭、神经损伤、视力问题和免疫力减弱状况,这些并发症可能会升级为危及生命的疾病,如心脏病发作、中风和失明。血糖是人体重要的能量来源,由胰岛素和胰高血糖素等激素调节。糖尿病的出现要么是由于身体对胰岛素产生抵抗,要么是由于胰腺中产生胰岛素的细胞受到自身免疫破坏。基于这些生理学见解,我们通过纳入一些新参数、引入饮食摄入隔室,并在分形 - 分数导数的意义上采用新的分数算子,对血糖 - 胰岛素(MBGI)模型进行了重新构建,以更好地捕捉该疾病的复杂动态。本研究通过定点方法,特别是勒雷 - 绍德尔技术,研究了解的存在性、唯一性和赫尔斯 - 乌拉姆稳定性。此外,还开发了一种基于牛顿多项式插值的数值方案,以可视化模型的行为。所得结果表明,分形维数和分数阶的增加都会导致血糖浓度显著降低,为糖尿病的有效管理和控制提供了有价值的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68b2/12134202/4502d08edeeb/41598_2025_4416_Fig1_HTML.jpg

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