Zhang Qin, Zhou Jinsong, Cao Changchun, Hu Haofei, Han Yong
Department of Anesthesiology, Longgang Central Hospital of Shenzhen, Shenzhen, 518000, Guangdong Province, China.
Department of Laboratory Medicine, Shenzhen Second People's Hospital, Shenzhen, 518035, Guangdong Province, China.
Sci Rep. 2025 Jun 3;15(1):19402. doi: 10.1038/s41598-025-05123-9.
The correlation between body mass index (BMI) and the outcomes for patients receiving surgical intervention for abdominal aortic aneurysm (AAA) is still debated. Consequently, this study seeks to investigate the association between BMI and mortality following elective open abdominal aortic aneurysm repair (EOAR). This study involves a secondary analysis derived from data collected in a prospective cohort framework. It focuses on individuals who received EOAR across ten vascular surgery centers in Denmark from January 1, 2000, to December 31, 2014. The analysis employed a Cox proportional hazards regression model to examine the connection between BMI and mortality following EOAR. To detect any potential nonlinear associations, Cox regression with cubic spline functions and smooth curve fitting was utilized. Furthermore, we performed numerous sensitivity and subgroup evaluations to ensure the reliability of our results. Upon controlling confounding variables, the analysis demonstrated a clear inverse correlation between BMI and mortality following EOAR. Specifically, each 1 kg/m² increase in BMI corresponded to a 2.7% reduction in mortality risk (HR = 0.973; 95% CI: 0.958-0.988). Compared to individuals with normal weight, those classified as underweight faced a 62.6% higher risk of mortality (HR = 1.626; 95% CI: 1.142-2.314), whereas overweight and obese individuals experienced a reduction in mortality risk by 18.2% (HR = 0.818; 95% CI: 0.722-0.928) and 15.8% (HR = 0.842; 95% CI: 0.721-0.998), respectively. Additionally, the study identified a nonlinear relationship between BMI and postoperative mortality, with a critical point at a BMI of 25.78 kg/m². Below this inflection point, each 1 kg/m² decrease in BMI significantly increased mortality risk by 8% (HR = 0.920; 95% CI: 0.893-0.949). Beyond this inflection point, further increases in BMI did not significantly impact mortality risk. In patients undergoing EOAR, an increase in BMI is significantly negatively associated with postoperative mortality. Additionally, a specific nonlinear relationship exists between BMI and postoperative mortality, with a BMI inflection point at 25.78 kg/m². Clinicians should carefully weigh surgical risks for patients with a BMI under 25.78 kg/m² and consider delaying surgery to enhance nutrition. In contrast, those overweight or obese may not require pre-surgery weight management.
体重指数(BMI)与接受腹主动脉瘤(AAA)手术干预患者的预后之间的相关性仍存在争议。因此,本研究旨在调查BMI与择期开放性腹主动脉瘤修复术(EOAR)后死亡率之间的关联。本研究涉及一项从前瞻性队列框架中收集的数据进行的二次分析。它聚焦于2000年1月1日至2014年12月31日期间在丹麦十个血管外科中心接受EOAR的个体。该分析采用Cox比例风险回归模型来检验BMI与EOAR后死亡率之间的联系。为了检测任何潜在的非线性关联,使用了带有三次样条函数和光滑曲线拟合的Cox回归。此外,我们进行了多次敏感性和亚组评估以确保结果的可靠性。在控制混杂变量后,分析表明BMI与EOAR后死亡率之间存在明显的负相关。具体而言,BMI每增加1kg/m²,死亡风险降低2.7%(HR = 0.9 seventy-three; 95% CI: 0.958 - 0.988)。与体重正常的个体相比,体重过轻的个体面临的死亡风险高62.6%(HR = 1.626; 95% CI: 1.142 - 2.314),而超重和肥胖个体的死亡风险分别降低了18.2%(HR = 0.818; 95% CI: 0.722 - 0.928)和15.8%(HR = 0.842; 95% CI: 0.721 - 0.998)。此外,该研究确定了BMI与术后死亡率之间的非线性关系,临界点为BMI 25.78kg/m²。低于这个拐点,BMI每降低1kg/m²,死亡风险显著增加8%(HR = 0.920; 95% CI: 0.893 - 0.949)。超过这个拐点,BMI的进一步增加对死亡风险没有显著影响。在接受EOAR的患者中,BMI的增加与术后死亡率显著负相关。此外,BMI与术后死亡率之间存在特定的非线性关系,BMI拐点为25.78kg/m²。临床医生应仔细权衡BMI低于25.78kg/m²患者的手术风险,并考虑推迟手术以加强营养。相比之下,超重或肥胖者可能不需要术前体重管理。
需注意,原文中“HR = 0.973”等数据后的中文表述中数字与英文原文不一致,推测是原文表述有误,这里按照正常翻译未对错误数字进行修改。