用氯丙嗪和氟哌啶醇处理的青蛙横纹肌中的快速冷却挛缩
Rapid cooling contracture in frog striated muscles treated with chlorpromazine and haloperidol.
作者信息
Matsubara S, Omori T
出版信息
Jpn J Physiol. 1985;35(2):335-41. doi: 10.2170/jjphysiol.35.335.
Rapid cooling contracture (RCC) was observed in frog toe muscles pretreated with caffeine, chlorpromazine (CPZ), or haloperidol (HPD). During rapid cooling contracture in the presence of caffeine (caffeine-RCC) tension developed to more than 0.8 of the maximum tetanic tension (P0). CPZ inhibited twitch but induced rapid cooling contracture (CPZ-RCC) between 50 and 150 microM; the tension saturated at the level of 0.75 P0 at 100 microM. HPD also inhibited twitch and induced rapid cooling contracture (HPD-RCC) at concentrations greater than 25 microM; the maximum tension was 0.25 P0. In the presence of dantrolene (10 microM), the tension during CPZ-RCC was reduced by 40%. Procaine (0.25%) reduced the CPZ-RCC tension by as much as 60%. These results suggest that CPZ and HPD induced rapid cooling contracture by reducing Ca2+-accumulation in sarcoplasmic reticulum.
在预先用咖啡因、氯丙嗪（CPZ）或氟哌啶醇（HPD）处理过的青蛙趾肌中观察到快速冷却挛缩（RCC）。在咖啡因存在下的快速冷却挛缩（咖啡因-RCC）过程中，张力发展到最大强直张力（P0）的0.8以上。CPZ在50至150微摩尔之间抑制抽搐但诱导快速冷却挛缩（CPZ-RCC）；在100微摩尔时，张力在0.75 P0水平达到饱和。HPD在浓度大于25微摩尔时也抑制抽搐并诱导快速冷却挛缩（HPD-RCC）；最大张力为0.25 P0。在丹曲林（10微摩尔）存在下，CPZ-RCC期间的张力降低了40%。普鲁卡因（0.25%）使CPZ-RCC张力降低多达60%。这些结果表明，CPZ和HPD通过减少肌浆网中Ca2+的积累诱导快速冷却挛缩。
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