吡嗪衍生物的研究。第七部分。某些吡嗪脒和偕胺肟的合成及其抑菌活性
Studies on pyrazine derivatives. Part VII. Synthesis and tuberculostatic activity of some pyrazine amidines and amidoximes.
作者信息
Foks H, Janowiec M
出版信息
Pol J Pharmacol Pharm. 1977 Jan-Feb;29(1):61-8.
PMID:404633
Abstract
In the reaction of 2-cyano-6-alkylaminopyrazines with sec. amines in the presence of anhyd. AlCl3 amidines 1-13 were obtained. From pyrazine-2-imidoesters, 2-cyano-pyrazines and pyrazine-2-carbothioamides and hydroxylamine, amidoximes 14-49 were easily prepared. These new compounds were, however, of little tuberculostatic activity (MIC between 31.5-2000 mug/cm3).
摘要
在无水三氯化铝存在下，2-氰基-6-烷基氨基吡嗪与仲胺反应可得到脒1-13。由吡嗪-2-亚胺酯、2-氰基吡嗪、吡嗪-2-碳硫酰胺和羟胺可轻松制备偕胺肟14-49。然而，这些新化合物的抑菌活性很小（最低抑菌浓度在31.5 - 2000微克/立方厘米之间）。
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