[吡嗪衍生物的研究。第二十七部分。某些6-烷氧基吡嗪-2-碳硫酰胺的合成及抑菌活性]
[Investigations of pyrazine derivatives. Part XXVII. Synthesis and tuberculostatic activity of some 6-alkoxypyrazine-2-carbotioamids].
作者信息
Milczarska B, Foks H, Janowiec M, Zwolska-Kwiek Z
机构信息
Zaklad Chemii Organicznej, Akademia Medyczna, ul. K. Marksa 107, 80-416 Gdańsk.
出版信息
Acta Pol Pharm. 1992;49(5-6):41-5.
PMID:16092199
Abstract
It was found that reaction of sodium alcoholates and cyanopyrazine yields alkoxypyrazine-nitriles. In heterogenic reaction both 2-alkylimidesters-6-chloropyrazine or 2-alkylimidoesters-6-alkoxypyrazine can be obtained dependent. This is dependent on quantity of alcohol used for reaction. Final products, alkoxypyrazinethioamides were tested for tuberculostatic activity (MIC within 31-500 mcg/cm3).
摘要
已发现醇钠与氰基吡嗪反应生成烷氧基吡嗪腈。在多相反应中，根据反应所用醇的量，可分别得到2 - 烷基亚氨基酯 - 6 - 氯吡嗪或2 - 烷基亚氨基酯 - 6 - 烷氧基吡嗪。对最终产物烷氧基吡嗪硫代酰胺进行了抑菌活性测试（最低抑菌浓度在31 - 500微克/立方厘米范围内）。
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