Zhang Jing, Wu Kai, Zhou Lin, Zheng Shusen
Department of Plastic and Aesthetic Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, People's Republic of China.
Spine Lab, Department of Orthopedic Surgery, The First Affiliated Hospital of Zhejiang University, Hangzhou, 310003, People's Republic of China.
J Multidiscip Healthc. 2025 May 30;18:3023-3037. doi: 10.2147/JMDH.S522203. eCollection 2025.
Adipose-derived stem cells (ADSCs) have shown great potential in cartilage tissue engineering (TE) due to their accessibility, high proliferation rate, and chondrogenic differentiation capacity. This study aims to systematically evaluate research trends, collaboration patterns, and emerging themes in ADSC-based cartilage TE through a bibliometric analysis, providing actionable insights to address knowledge gaps and advance the field.
A systematic search was conducted on the Web of Science Core Collection (WoSCC) database to identify publications related to ADSCs and cartilage TE. Bibliometric and visualized analysis was performed using VOSviewers (V 1.6.20), CiteSpace (V 6.3.R1) and Bibliometrix (R 4.3.3).
A total of 436 English articles were analyzed, involving 2356 authors from 1532 institutions across 50 countries/regions, contributing to 189 journals. The annual growth rate of publications was 8.73%, peaking in 2021. China contributed the most articles (n=127, 29.1%), followed by the USA (n=65, 14.9%). Leading institutions included Kaohsiung Medical University and Duke University. had the highest H-index (21) and the most publications (n = 26). Reis Rui L. and Gomes Manuela E. were among the most influential contributors. Keyword analysis revealed an early focus on "in-vitro" studies and "bone-marrow", which later transitioned to "chondrogenic differentiation", "growth", and "regeneration". Recent trends since 2020 include "3D printing", "mesenchymal stem cells", and "cartilage repair", reflecting the field's evolution towards advanced technologies and translational applications.
This bibliometric analysis provides valuable guidance for researchers, clinicians, and policymakers, emphasizing the necessity of addressing translational challenges and fostering global collaboration to develop clinically effective solutions for cartilage repair and regeneration.
脂肪来源干细胞（ADSCs）因其易获取性、高增殖率和成软骨分化能力，在软骨组织工程（TE）中显示出巨大潜力。本研究旨在通过文献计量分析系统评估基于ADSCs的软骨TE的研究趋势、合作模式和新兴主题，为填补知识空白和推动该领域发展提供可行见解。
在科学网核心合集（WoSCC）数据库中进行系统检索，以识别与ADSCs和软骨TE相关的出版物。使用VOSviewer（V 1.6.20）、CiteSpace（V 6.3.R1）和Bibliometrix（R 4.3.3）进行文献计量和可视化分析。
共分析了436篇英文文章，涉及来自50个国家/地区1532个机构的2356名作者，发表于189种期刊。出版物的年增长率为8.73%，在2021年达到峰值。中国发表的文章最多（n = 127，29.1%），其次是美国（n = 65，14.9%）。主要机构包括高雄医学大学和杜克大学。 拥有最高的H指数（21）和最多的出版物（n = 26）。雷斯·鲁伊·L.和戈麦斯·曼努埃拉·E.是最具影响力的贡献者之一。关键词分析显示，早期关注“体外”研究和“骨髓”，后来转向“成软骨分化”“生长”和“再生”。2020年以来的最新趋势包括“3D打印 ”“间充质干细胞”和“软骨修复”，反映了该领域向先进技术和转化应用的发展。
本文献计量分析为研究人员、临床医生和政策制定者提供了有价值的指导，强调了应对转化挑战和促进全球合作以开发软骨修复和再生临床有效解决方案的必要性。
