Kim Tae-Young, Oh Ye-In
Jukjeon Animal Medical Center, Dalgubeol-daero, Daegu, Republic of Korea.
Department of Veterinary Internal Medicine, College of Veterinary Medicine and Institute for Veterinary Biomedical Science, Kyungpook National University, Daegu, Republic of Korea.
Front Vet Sci. 2025 May 20;12:1570221. doi: 10.3389/fvets.2025.1570221. eCollection 2025.
Porcelain Gallbladder (PGB) is a condition marked by extensive calcification and thickening of the gallbladder wall. PGB is extremely rare in dogs. The exact mechanism of PGB remains unclear. However, chronic cholecystitis and factors such as biliary hyperplasia, mucin hypersecretion, and cystic duct obstruction can lead to fibrosis and calcification of the gallbladder wall, potentially resulting in PGB. A 13-year-old spayed female Shih Tzu presented with anorexia, lethargy, vomiting, and weight loss. Physical exams showed mild epigastric pain. Blood tests indicated mild alanine aminotransferase (ALT) elevation, significant alkaline phosphatase, and gamma-glutamyl transferase (GGT) increases. Hyperlipidemia, hypercholesterolemia, and elevated canine pancreatic lipase (cPL) were also noted. Diagnostic imaging revealed extensive gallbladder wall calcification and thickening, choleliths, mild bile duct dilation, pancreatitis, and duodenitis. Cholecystectomy was performed, and symptomatic treatment for pancreatitis and duodenitis was administered. Histopathological examination is essential for confirming PGB by identifying calcification of the gallbladder wall. Histopathological examination of the gallbladder revealed severe papillary hyperplasia, mucin hypersecretion, multiple ulcers, diffuse calcification, and fibrotic changes. These findings confirmed the diagnoses of gallbladder mucocele and PGB. Postoperatively, biochemical markers normalized or significantly decreased, with clinical improvement observed. This study presents the rare occurrence of PGB in dogs and emphasizes the importance of appropriate veterinary intervention for improving clinical outcomes.
瓷胆囊（PGB）是一种以胆囊壁广泛钙化和增厚为特征的病症。PGB在犬类中极为罕见。PGB的确切发病机制尚不清楚。然而，慢性胆囊炎以及诸如胆管增生、粘蛋白分泌过多和胆囊管梗阻等因素可导致胆囊壁纤维化和钙化，有可能引发PGB。一只13岁已绝育的雌性西施犬出现厌食、嗜睡、呕吐和体重减轻症状。体格检查显示上腹部轻度疼痛。血液检测表明丙氨酸转氨酶（ALT）轻度升高，碱性磷酸酶和γ-谷氨酰转移酶（GGT）显著升高。还发现有高脂血症、高胆固醇血症以及犬胰脂肪酶（cPL）升高。诊断性影像学检查显示胆囊壁广泛钙化和增厚、胆结石、轻度胆管扩张、胰腺炎和十二指肠炎症。实施了胆囊切除术，并对胰腺炎和十二指肠炎症进行了对症治疗。组织病理学检查对于通过识别胆囊壁钙化来确诊PGB至关重要。胆囊的组织病理学检查显示严重的乳头状增生、粘蛋白分泌过多、多处溃疡、弥漫性钙化和纤维化改变。这些发现证实了胆囊黏液囊肿和PGB的诊断。术后，生化指标恢复正常或显著下降，临床症状有所改善。本研究呈现了犬类中PGB的罕见病例，并强调了适当的兽医干预对改善临床结果的重要性。
