Brömel C, Smeak D D, Léveillé R
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210, USA.
J Am Vet Med Assoc. 1998 Oct 15;213(8):1137-9, 1131.
A 9-year-old spayed female Poodle was admitted because of vomiting of 3 weeks' duration, lethargy, and anorexia. Palpation of the cranial portion of the abdomen elicited signs of pain. Principal laboratory abnormalities included mild segmented neutrophilia, lymphopenia, high serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase activities, and hyperbilirubinemia. Radiography revealed foamy appearing areas of mineral opacity in the region of the gallbladder. Ultrasonographically, a hyperechoic structure with acoustic shadowing was seen in the same region, and extrahepatic bile ducts were distended. Cholecystectomy was performed. The gallbladder wall felt thicker than normal and was bluish-white. Multiple choleliths were found in the gallbladder and extrahepatic bile ducts. Histologic examination revealed chronic proliferative lymphoplasmacytic cholecystitis with mineralization and a well-differentiated adenocarcinoma of the gallbladder neck. A diagnosis of porcelain gallbladder was made. The dog recovered without complications and was healthy 14 months after surgery. To our knowledge, porcelain gallbladder has not been reported in dogs. In human patients, it is defined as intramural mineralization of the gallbladder commonly associated with gallbladder neoplasia. Early recognition is important for appropriate surgical treatment.
一只9岁已绝育的雌性贵宾犬因持续3周的呕吐、嗜睡和厌食而入院。触诊腹部前部有疼痛迹象。主要实验室异常包括轻度分叶核粒细胞增多、淋巴细胞减少、血清丙氨酸氨基转移酶、天冬氨酸氨基转移酶和碱性磷酸酶活性升高以及高胆红素血症。放射学检查显示胆囊区域有泡沫状的矿物质不透明区。超声检查发现同一区域有一个伴有声影的高回声结构，肝外胆管扩张。进行了胆囊切除术。胆囊壁比正常厚，呈蓝白色。在胆囊和肝外胆管中发现多个胆石。组织学检查显示为慢性增生性淋巴细胞浆细胞性胆囊炎伴矿化以及胆囊颈部高分化腺癌。诊断为瓷胆囊。这只狗术后恢复顺利，无并发症，术后14个月健康。据我们所知，犬类中尚未报道过瓷胆囊。在人类患者中，它被定义为胆囊壁内矿化，通常与胆囊肿瘤有关。早期识别对于适当的手术治疗很重要。
