Institute of Ultrasound Imaging, Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, No.76 Linjiang Road, Yuzhong District, Chongqing, 400010, China; Department of Ultrasound, The Fourth Affiliated Hospital of Chongqing Medical University, No.55 Daxuecheng Middle Road, Shapingba District, Chongqing, 400131, China.
Department of Ultrasound, The Fourth Affiliated Hospital of Chongqing Medical University, No.55 Daxuecheng Middle Road, Shapingba District, Chongqing, 400131, China.
Biochem Biophys Res Commun. 2024 Sep 3;723:150173. doi: 10.1016/j.bbrc.2024.150173. Epub 2024 May 24.
The utilization of photothermal agents (PTAs) in photothermal therapy (PTT) is faced with challenges such as immune clearance and inadequate concentration, which consequently result in residual tumors and an increased risk of recurrence and metastasis. Conversely, excessive treatment can lead to heightened inflammation and inevitable harm to adjacent healthy tissues. To address these issues, we developed a nanosystem (M@PB) consisting of Prussian blue coated with tumor cell membrane for precise photothermal therapy (PTT) and subsequent reduction of inflammation. This system not only evades immune attack due to the homologous biological characteristics of the encapsulating cell membrane but also exhibits active targeting capabilities towards homologous tumors. Furthermore, it effectively reduces excessive phototoxicity by leveraging the distinctive photothermal and anti-inflammatory characteristics of PB nanoparticles. The resulting M@PB nanosystem demonstrates effective photothermal ablation under 808 nm laser irradiation while mitigating the inflammatory response through inhibiting of local production of inflammatory mediators. Our study provides valuable insights into achieving targeted PTT with high efficiency while minimizing post-treatment inflammatory responses.
光热剂（PTAs）在光热治疗（PTT）中的应用面临着免疫清除和浓度不足等挑战，这会导致肿瘤残留、复发和转移的风险增加。相反，过度治疗会导致炎症加剧，不可避免地对相邻的健康组织造成伤害。为了解决这些问题，我们开发了一种由普鲁士蓝包覆的肿瘤细胞膜组成的纳米系统（M@PB），用于精确的光热治疗（PTT）和随后的炎症减轻。该系统不仅由于封装细胞膜的同源生物学特性而避免了免疫攻击，还表现出对同源肿瘤的主动靶向能力。此外，它还通过利用 PB 纳米粒子独特的光热和抗炎特性，有效地减少了过度的光毒性。所得到的 M@PB 纳米系统在 808nm 激光照射下表现出有效的光热消融作用，同时通过抑制局部炎症介质的产生来减轻炎症反应。我们的研究为实现高效的靶向 PTT 并最小化治疗后的炎症反应提供了有价值的见解。
