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在我的疾病历程中靶向“野兽”:一项关于三阴性乳腺癌女性的定性研究

Targeting the Beast Along My Illness Trajectory: A Qualitative Study of Females With Triple-Negative Breast Cancer.

作者信息

Scerri Josianne, Agius Janice, Galea Michael

机构信息

Department of Mental Health, Faculty of Health Sciences, University of Malta, Msida, Malta.

Faculty of Health, Science, Social Care and Education, Kingston University, Surrey, UK.

出版信息

J Patient Exp. 2025 Jun 2;12:23743735251345475. doi: 10.1177/23743735251345475. eCollection 2025.

Abstract

Breast cancer subtypes differ in prevalence, aggressiveness, and availability of targeted therapies. However, research often examines the lived experiences of individuals with breast cancer collectively. One subtype, Triple-Negative Breast Cancer (TNBC) is an aggressive form of cancer that lacks targeted therapy and has higher recurrence and mortality rates. This study aims to explore the lived experiences of individuals diagnosed with TNBC, from diagnosis through active treatment. Audio-recorded interviews were conducted with 11 women who had completed treatment for TNBC. Ages ranged between 26 and 63 years. Data collected were analyzed using interpretative phenomenological analysis. Four group experiential themes were extracted: "Living in shellshock," "Fighting the aggressive beast," "Pulling out the beast," and "Facing the unknown." Participants described substantial emotional distress stemming from the aggressive progression of TNBC and its earlier onset. The rarity of TNBC further intensified perceptions of reduced survival odds. This study underscores the importance of comprehensive care for TNBC patients, incorporating ongoing engagement with TNBC survivors, access to mental health services, and inclusive screening that includes younger women.

摘要

乳腺癌亚型在患病率、侵袭性和靶向治疗的可及性方面存在差异。然而,研究通常将乳腺癌患者的生活经历作为一个整体来考察。其中一种亚型,三阴性乳腺癌(TNBC)是一种侵袭性癌症,缺乏靶向治疗,复发率和死亡率更高。本研究旨在探索被诊断为TNBC的患者从确诊到积极治疗期间的生活经历。对11名完成TNBC治疗的女性进行了录音访谈。年龄在26岁至63岁之间。使用解释性现象学分析对收集到的数据进行了分析。提取了四个群体体验主题:“生活在极度震惊中”、“对抗侵袭性病魔”、“根除病魔”和“面对未知”。参与者描述了TNBC的侵袭性进展及其较早发病所带来的巨大情绪困扰。TNBC的罕见性进一步加剧了对生存几率降低的认知。本研究强调了为TNBC患者提供全面护理的重要性,包括持续与TNBC幸存者接触、提供心理健康服务以及对包括年轻女性在内的人群进行包容性筛查。

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