Jiménez-Alonso Ana A, Pérez-Santana Carmen G, Cazorla-Rivero Sara E, Rodríguez-Esparragón Francisco, Rodríguez Grau-Bassas Enrique
Department of Sanidad Animal, Instituto Universitario de Sanidad Animal Y Seguridad Alimentaria (IUSA), Universidad de Las Palmas de Gran Canaria (ULPGC), Arucas, Las Palmas, 35400, Spain.
Department of Investigación, Instituto Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Las Palmas, 35010, Spain.
Vet Med (Auckl). 2025 May 28;16:1-8. doi: 10.2147/VMRR.S500469. eCollection 2025.
Canine cutaneous squamous cell carcinoma (SCC) is a locally invasive tumor with a variable prognosis.
This study evaluated clinical stage and histopathological grade as prognostic factors. Eleven dogs with inguinal SCC underwent surgery. All dogs presented varying degrees of atopic skin owing to prolonged outdoor ultraviolet (UV) exposure. Tumors are located primarily in the ventro inguinal area, affecting the prepuce and scrotum in males. Clinical staging (TNM system) was performed through abdominal ultrasound and palpation of regional lymph nodes, and histopathologically, Broder grading was applied.
The survival time (ST) and disease-free interval (DFI) were analyzed, and the median ST was 738 days for Grade 1 tumors compared with 135 days for Grade 4 tumors. Staging correlated with metastatic risk (1/11 patients).
This study highlights the importance of histological grade as a prognostic factor for canine cutaneous SCC and surgery as a treatment of choice and emphasizes the need for further studies on disease progression and treatment outcomes in veterinary medicine.
犬皮肤鳞状细胞癌（SCC）是一种具有不同预后的局部浸润性肿瘤。
本研究评估临床分期和组织病理学分级作为预后因素。11只患有腹股沟SCC的犬接受了手术。由于长期户外紫外线（UV）暴露，所有犬均呈现不同程度的特应性皮炎。肿瘤主要位于腹侧腹股沟区，在雄性犬中影响包皮和阴囊。通过腹部超声和区域淋巴结触诊进行临床分期（TNM系统），组织病理学上采用布罗德分级。
分析了生存时间（ST）和无病间期（DFI），1级肿瘤的中位ST为738天，而4级肿瘤为135天。分期与转移风险相关（1/11例患者）。
本研究强调了组织学分级作为犬皮肤SCC预后因素的重要性以及手术作为首选治疗方法的重要性，并强调需要进一步研究兽医学中疾病进展和治疗结果。
