de Castro Cunha Rúbia Monteiro, Lavalle Gleidice Eunice, Nunes Fernanda Camargo, de Oliveira Ayisa Rodrigues, de Lima Santos Renato, de Araújo Roberto Baracat
Department of Veterinary Clinic and Surgery, Veterinary School, Veterinary Hospital, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
Faculdade Murialdo, Veterinary School, Caxias do Sul, Brazil.
Vet Comp Oncol. 2023 Jun;21(2):240-254. doi: 10.1111/vco.12882. Epub 2023 Mar 5.
Squamous cell carcinoma (SCC) is an important malignancy in dogs, due to its incidence and clinical presentation, which can be of locally aggressive single or multiple lesions with a metastatic potential. The objective of this investigation was to evaluate SCC response to treatment, anatomopathological and immunohistochemical characteristics, disease-free interval and overall survival time. 54 dogs with histopathologically diagnosed SCC were included in this study. Their mean age was 9.16 years with a range of 1-14 years. Of the 54 animals in the study, 34 (65.4%) had white skin and white fur coats. There was a significant correlation between fur coat colour and the development of tumours in areas of sun exposure (p = .001). Animals with tumours in areas of the body exposed to the sun had longer overall survival time than animals with tumours in areas not associated with sun exposure (p = .001). Surgery combined with electrochemotherapy (ECT) yielded a survival rate 32% higher than using a surgical approach alone (HR = 0.32, p = .038, IC = 0.11-0.94). ECT, with or without surgery, had an objective response rate of 90.9%. Local lymph node and/or distant site metastasis at diagnosis, or at some point during follow-up, occurred in 34.6% (18/52) of animals. Animals with tumours in sun exposed locations had more aggressive histopathological characteristics but had longer overall survival time. This is probably due to individualised therapeutic treatment with both surgery and ECT.
鳞状细胞癌（SCC）是犬类的一种重要恶性肿瘤，鉴于其发病率和临床表现，它可能表现为具有转移潜能的局部侵袭性单发性或多发性病变。本研究的目的是评估SCC对治疗的反应、解剖病理学和免疫组织化学特征、无病生存期和总生存时间。本研究纳入了54只经组织病理学诊断为SCC的犬。它们的平均年龄为9.16岁，范围在1至14岁之间。在研究的54只动物中，34只（65.4%）有白色皮肤和白色被毛。被毛颜色与阳光暴露部位肿瘤的发生之间存在显著相关性（p = 0.001）。身体阳光暴露部位有肿瘤的动物比非阳光暴露部位有肿瘤的动物总生存时间更长（p = 0.001）。手术联合电化学疗法（ECT）的生存率比单独使用手术方法高32%（风险比=0.32，p = 0.038，可信区间=0.11 - 0.94）。ECT无论是否联合手术，客观缓解率均为90.9%。34.6%（18/52）的动物在诊断时或随访期间的某个时间点出现局部淋巴结和/或远处转移。阳光暴露部位有肿瘤的动物具有更具侵袭性的组织病理学特征，但总生存时间更长。这可能是由于手术和ECT的个体化治疗。
