Barnaba Paolo, Rosa Alessio, Gargari Marco, Martelli Mirko
Department of Clinical Sciences and Translational Medicine, University of Rome tor Vergata, Rome, Italy.
Aust Endod J. 2025 Aug;51(2):431-437. doi: 10.1111/aej.12960. Epub 2025 Jun 4.
This systematic review investigates the clinical use of bioceramic materials in retrograde apicectomy, a surgical endodontic procedure aimed at managing persistent periapical pathology. The review follows the PRISMA 2020 guidelines and is registered in PROSPERO (CRD420251022135). Comprehensive searches were conducted in PubMed, Scopus, and Web of Science from January 2000 to December 2024. Studies were included if they were human clinical trials evaluating bioceramic materials in retrograde apicectomies with a minimum follow-up of 6 months. Data extraction included sample size, material type, healing outcomes, and complications. Nineteen studies met the inclusion criteria. Findings indicated that bioceramics demonstrated superior sealing ability, biocompatibility, and osteoconductive properties compared to traditional materials such as amalgam or IRM. The analysis highlights the effectiveness of mineral trioxide aggregate (MTA) and newer formulations such as bioceramic putty and premixed hydraulic silicate cements. Bioceramics are positioned as a promising standard in apical surgery, though further long-term controlled studies are warranted.
本系统评价研究了生物陶瓷材料在根尖倒充填术中的临床应用，根尖倒充填术是一种牙髓外科手术，旨在处理持续性根尖周病变。该评价遵循PRISMA 2020指南，并已在PROSPERO（CRD420251022135）注册。于2000年1月至2024年12月在PubMed、Scopus和Web of Science中进行了全面检索。纳入的研究需为评估生物陶瓷材料用于根尖倒充填术的人体临床试验，且随访时间至少为6个月。数据提取包括样本量、材料类型、愈合结果和并发症。19项研究符合纳入标准。研究结果表明，与汞合金或IRM等传统材料相比，生物陶瓷具有更好的封闭能力、生物相容性和骨传导性能。分析突出了三氧化矿物凝聚体（MTA）以及生物陶瓷糊剂和预混水硬性硅酸盐水泥等新型制剂的有效性。尽管需要进一步开展长期对照研究，但生物陶瓷在根尖手术中有望成为一种有前景的标准材料。
