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病例评论：阿奇霉素局部珠剂药代动力学的艰巨研究

Case Commentary: A herculean effort for -localized azithromycin bead pharmacokinetics.

作者信息

Tsai Shemual, Grimes Kevin

机构信息

Department of Pharmacy, Houston Methodist Hospital, Houston, Texas, USA.

Division of Infectious Diseases, Department of Internal Medicine, Houston Methodist Hospital, Houston, Texas, USA.

出版信息

Antimicrob Agents Chemother. 2025 Jun 4;69(6):e0030525. doi: 10.1128/aac.00305-25. Epub 2025 Apr 23.

DOI:10.1128/aac.00305-25
PMID:40464553
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12135523/
Abstract

Non-tuberculous mycobacterial infections present significant treatment challenges due to resistance and limited data on optimal antibiotic regimens. A recently published case report provided an innovative approach to hand tenosynovitis with azithromycin-loaded calcium sulfate beads and valuable pharmacokinetic data with concentration measurements. This case demonstrates the ability of azithromycin-loaded calcium sulfate beads to achieve high local tissue concentrations with low systemic toxicity.

摘要

非结核分枝杆菌感染由于耐药性以及关于最佳抗生素治疗方案的数据有限，带来了重大的治疗挑战。最近发表的一篇病例报告提供了一种用载有阿奇霉素的硫酸钙珠治疗手部腱鞘炎的创新方法，并通过浓度测量提供了有价值的药代动力学数据。该病例证明了载有阿奇霉素的硫酸钙珠能够在全身毒性较低的情况下实现较高的局部组织浓度。

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本文引用的文献

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Treatment for non-tuberculous mycobacteria: challenges and prospects.非结核分枝杆菌的治疗：挑战与前景
Front Microbiol. 2024 Jun 3;15:1394220. doi: 10.3389/fmicb.2024.1394220. eCollection 2024.
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Limitations and modifications in the clinical application of calcium sulfate.硫酸钙临床应用中的局限性与改进措施
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The efficacy of antibiotic-impregnated calcium sulfate (AICS) in the treatment of infected non-union and fracture-related infection: a systematic review.抗生素浸渍硫酸钙（AICS）治疗感染性骨不连及骨折相关感染的疗效：一项系统评价
J Bone Jt Infect. 2023 Mar 22;8(2):91-97. doi: 10.5194/jbji-8-91-2023. eCollection 2023.
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Simulated large joint fluid model for evaluating intra-articular antibiotic delivery systems: initial evaluation using antibiotic-loaded calcium sulfate beads.用于评估关节腔内抗生素递送系统的模拟大关节液模型：使用载抗生素硫酸钙珠的初步评估
J Bone Jt Infect. 2022 May 17;7(3):117-125. doi: 10.5194/jbji-7-117-2022. eCollection 2022.
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Antibiotic-loaded calcium sulfate in clinical treatment of chronic osteomyelitis: a systematic review and meta-analysis.载抗生素硫酸钙在慢性骨髓炎临床治疗中的应用：系统评价和荟萃分析。
J Orthop Surg Res. 2022 Feb 19;17(1):104. doi: 10.1186/s13018-022-02980-2.
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Antibiotics (Basel). 2021 Mar 8;10(3):270. doi: 10.3390/antibiotics10030270.
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