病例评论：阿奇霉素局部珠剂药代动力学的艰巨研究
Case Commentary: A herculean effort for -localized azithromycin bead pharmacokinetics.
作者信息
Tsai Shemual, Grimes Kevin
机构信息
Department of Pharmacy, Houston Methodist Hospital, Houston, Texas, USA.
Division of Infectious Diseases, Department of Internal Medicine, Houston Methodist Hospital, Houston, Texas, USA.
出版信息
Antimicrob Agents Chemother. 2025 Jun 4;69(6):e0030525. doi: 10.1128/aac.00305-25. Epub 2025 Apr 23.
Abstract
Non-tuberculous mycobacterial infections present significant treatment challenges due to resistance and limited data on optimal antibiotic regimens. A recently published case report provided an innovative approach to hand tenosynovitis with azithromycin-loaded calcium sulfate beads and valuable pharmacokinetic data with concentration measurements. This case demonstrates the ability of azithromycin-loaded calcium sulfate beads to achieve high local tissue concentrations with low systemic toxicity.
摘要
非结核分枝杆菌感染由于耐药性以及关于最佳抗生素治疗方案的数据有限，带来了重大的治疗挑战。最近发表的一篇病例报告提供了一种用载有阿奇霉素的硫酸钙珠治疗手部腱鞘炎的创新方法，并通过浓度测量提供了有价值的药代动力学数据。该病例证明了载有阿奇霉素的硫酸钙珠能够在全身毒性较低的情况下实现较高的局部组织浓度。
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