Fang Quanjun, Mao Jilai, Fu Canya, Gong Xiaoying, Zheng Canjie, Yin Zhiying
Department of Immunity, Quzhou Center for Disease Control and Prevention, Quzhou, Zhejiang, China.
Department of Immunity, Jiangshan Center for Disease Control and Prevention, Zhejiang, China.
Hum Vaccin Immunother. 2025 Dec;21(1):2512642. doi: 10.1080/21645515.2025.2512642. Epub 2025 Jun 4.
Despite the implementation of a two-dose varicella vaccine (VarV) immunization strategy for over a decade in Quzhou, China, outbreaks of varicella continue to be reported in school settings with high vaccination coverage. This cross-sectional study surveyed healthy individuals aged 3 to 20 years across six districts and counties in Quzhou, China. Serum samples were collected to detect varicella-zoster virus (VZV) IgG antibodies and to evaluate the effectiveness of the two-dose VarV immunization strategy. Among the 1,020 participants, the overall seropositivity rate for VZV IgG was 57.16%, with a median concentration (MC) of 136.46 mIU/mL. Multivariable logistic regression analysis revealed that VZV IgG seropositivity was associated with residence, age group, and VarV immunization history. Single-dose recipients exhibited an antibody peak at 4.34 years, followed by decline to a nadir at 7.95 years and subsequent rebound. In two-dose recipients, antibody levels declined rapidly within the first 1.82 years post-vaccination, followed by a gradual downward trend; nevertheless, levels consistently remained above the protective threshold of 100 mIU/mL. The necessity of booster immunization warrants further investigation.
尽管中国衢州实施两剂次水痘疫苗（VarV）免疫策略已达十多年，但在疫苗接种覆盖率较高的学校环境中仍不断有水痘暴发的报告。这项横断面研究对中国衢州六个区县3至20岁的健康个体进行了调查。采集血清样本以检测水痘带状疱疹病毒（VZV）IgG抗体，并评估两剂次VarV免疫策略的有效性。在1020名参与者中，VZV IgG的总体血清阳性率为57.16%，中位浓度（MC）为136.46 mIU/mL。多变量逻辑回归分析显示，VZV IgG血清阳性与居住地、年龄组和VarV免疫史有关。单剂次接种者在4.34岁时出现抗体峰值，随后在7.95岁时降至最低点，随后反弹。在两剂次接种者中，抗体水平在接种后最初1.82年内迅速下降，随后呈逐渐下降趋势；然而，其水平始终保持在100 mIU/mL的保护阈值以上。加强免疫的必要性值得进一步研究。
