Yuan Zhiruo, Bai Xiaoqiang, Li Sida, Fu Yu, Wan Zhuqing, Guo Xiaodong, Zhai Mo, Yi Jundan, Liu Yan, Zhou Yongsheng, Lv Longwei
Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No. 22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, P. R. China.
Fourth Clinical Division, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, 100081, P. R. China.
Adv Healthc Mater. 2025 Jul;14(18):e2500475. doi: 10.1002/adhm.202500475. Epub 2025 Jun 4.
3D bioprinting has been advanced from creating simple, static structures with single materials to sophisticated multimaterial and multidimensional designs. This evolution has improved printing precision, the range of application and dynamic functionality. Multimaterial and multidimensional bioprinting represent significant advancements in regenerative medicine. By integrating a range of materials and employing diverse printing techniques, these approaches address the limitations of single-material and fixed-dimension methods, thereby overcoming the constraints of traditional, uniform complexity. Multimaterial bioprinting fabricates additive manufacturing structures simultaneously with materials vary in composition and mechanical strength, which increases the complexity in biomedical applications. Meanwhile, multidimensional bioprinting involves incorporating additional dimensions (such as time or space) into printing process, which allows for dynamic configuration transformations and functional responses. Here, the basic concepts and components are summarized of multimaterial and multidimensional bioprinting, the medical adaptation is discussed and the advantages, challenges as well as future perspectives of current approaches are analyzed. Moreover, this review provides perspective on multimaterial and multidimensional bioprinting, and highlights new opportunities in regenerative medicine tissue engineering, particularly in bone tissue engineering bioprinting.
3D生物打印已经从使用单一材料创建简单的静态结构发展到复杂的多材料和多维设计。这种演变提高了打印精度、应用范围和动态功能。多材料和多维生物打印代表了再生医学的重大进步。通过整合一系列材料并采用多种打印技术，这些方法解决了单一材料和固定尺寸方法的局限性，从而克服了传统的、统一复杂性的限制。多材料生物打印在制造增材制造结构的同时，材料的成分和机械强度各不相同，这增加了生物医学应用的复杂性。与此同时，多维生物打印涉及将额外的维度（如时间或空间）纳入打印过程，这允许进行动态配置转换和功能响应。在此，总结了多材料和多维生物打印的基本概念和组成部分，讨论了医学应用，分析了当前方法的优势、挑战以及未来前景。此外，本综述提供了关于多材料和多维生物打印的观点，并强调了再生医学组织工程中的新机会，特别是在骨组织工程生物打印方面。
