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探索生物陶瓷支架制造中的制造技术,重点关注用于组织工程应用的直接墨水书写3D打印。

Exploring Manufacturing Techniques in Bioceramic Scaffold Fabrication with a Focus on DIW 3D Printing for Tissue Engineering Applications.

作者信息

Belgin Paul D L, Susila Praveen Ayyappan, Karthick M

机构信息

Department of Mechanical Engineering, Vel Tech Rangarajan Dr. Sagunthala R&D Institute of Science and Technology, Chennai, Tamil Nadu, 600062, India.

出版信息

Ann Biomed Eng. 2025 Apr 3. doi: 10.1007/s10439-025-03722-1.

Abstract

In recent years, notable advancements have been achieved in the domain of tissue engineering and regenerative medicine, presenting auspicious remedies for the management of diverse injuries and ailments. The management of bone injuries necessitates the implementation of a customized approach depending upon the specific nature of the injury. Tissue engineering plays a major role in the treatment of such bone injuries. One key aspect of tissue engineering is the development of scaffolds that can provide structural support and guide the growth of new tissue. The scaffold should possess mechanical properties that enable it to withstand weight-bearing stresses, resembling the strength and durability of real bone. This review explores the latest research findings from pioneering research papers in tissue engineering, focusing on scaffolds, bioceramics, and the various technique for the development of scaffolds with a focus on 3D printing. By examining and synthesizing key studies in these areas, this review aims to provide insights into the current state of knowledge, identify research gaps, and contribute to the advancement of tissue engineering approaches for regenerative medicine applications.

摘要

近年来,组织工程和再生医学领域取得了显著进展,为各种损伤和疾病的治疗提供了前景良好的解决方案。骨损伤的治疗需要根据损伤的具体性质采取定制化方法。组织工程在这类骨损伤的治疗中发挥着重要作用。组织工程的一个关键方面是开发能够提供结构支撑并引导新组织生长的支架。该支架应具备使其能够承受负重压力的机械性能,类似于真实骨骼的强度和耐久性。本综述探讨了组织工程领域开创性研究论文的最新研究成果,重点关注支架、生物陶瓷以及支架开发的各种技术,尤其侧重于3D打印。通过审视和综合这些领域的关键研究,本综述旨在深入了解当前的知识状态,识别研究空白,并为再生医学应用的组织工程方法的进步做出贡献。

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