Porto Ana Rafaela Antunes, Duval Isabela de Brito, do Amaral Luisa Vitor Braga, Oliveira Izabela da Silva, de Siqueira João Gabriel Acioli, de Albuquerque Bruno Araújo, Rocha Maria Alice Guarini, Lemos Gabriela Gomes Monteiro, Cardozo Marcelo Eduardo, Rihs José Bryan da Rocha, Fujiwara Ricardo Toshio, de Oliveira Ana Laura Grossi, Brito Ramayana Morais de Medeiros, Bueno Lilian Lacerda
Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Laboratório de Imunobiologia e Controle de Parasitos, Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Programa de Pós-Graduação em Parasitologia, Belo Horizonte, MG, Brasil.
Mem Inst Oswaldo Cruz. 2025 Jun 2;120:e240123. doi: 10.1590/0074-02760240123. eCollection 2025.
Plants represent an important source of compounds for treating malaria, highlighting the rich biodiversity of Brazilian flora as a vital resource for developing new, effective antimalarial drugs. The present study sought to shed light on the search for new compounds with antimalarial activity obtained from the Brazilian flora. In this sense, a systematic review was conducted using screening techniques based on "The Preferred Reporting Items for Systematic Reviews and Meta-Analysis" (PRISMA) protocol. Most of the plants collected in the studies were from the Amazon Rainforest, north of Brazil. Most of the isolated compounds were from the Apocynaceae family and the alkaloids were the main compounds isolated with significant antiplasmodial activity, followed by flavonoids and phenolic compounds. The Brazilian flora can source many compounds with potential antimalarial activity that can challenge Plasmodium drug resistance. However, new studies are still needed to elucidate the natural compounds activity for future application in Malaria treatment.
植物是治疗疟疾的化合物的重要来源，凸显了巴西丰富的植物生物多样性是开发新型有效抗疟药物的重要资源。本研究旨在阐明从巴西植物群中寻找具有抗疟活性的新化合物的情况。从这个意义上说，根据“系统评价和荟萃分析的首选报告项目”（PRISMA）方案，采用筛选技术进行了系统评价。研究中收集的大多数植物来自巴西北部的亚马逊雨林。大多数分离出的化合物来自夹竹桃科，生物碱是分离出的具有显著抗疟原虫活性的主要化合物，其次是黄酮类化合物和酚类化合物。巴西植物群可以提供许多具有潜在抗疟活性的化合物，这些化合物可以对抗疟原虫的耐药性。然而，仍需要新的研究来阐明天然化合物的活性，以便未来应用于疟疾治疗。
