Baptista Fim Alana, Benetti-Pinto Cristina Laguna, Yela Daniela Angerame
Universidade Estadual de Campinas, School of Medical Sciences, Department of Gynecology and Obstetrics - Campinas (SP), Brazil.
Rev Assoc Med Bras (1992). 2025 Jun 2;71(4):e20241525. doi: 10.1590/1806-9282.20241525. eCollection 2025.
The aim of this study was to evaluate the effectiveness of hysteroscopic myomectomy in the symptoms of women with uterine myomatosis.
This is a retrospective cohort study conducted on 119 women with uterine myomatosis who underwent hysteroscopic myomectomy in a tertiary hospital from 2018 to 2023. Women of reproductive age diagnosed with submucosal myoma who underwent hysteroscopic myomectomy were included, and women who did not have the data in their medical records necessary for completion were excluded. The sociodemographic and clinical variables of these women were evaluated.
The average age of the women was 41.4±6.8 years. Among the fibroids, 37.0% were International Federation of Gynecology and Obstetrics (FIGO) 0 and 52.5% were FIGO 1. The average size of the fibroids was 2.7±1.4 cm. There were 10.0% of complications. After myomectomy, 67.2% of the women had improvement in symptoms, 66.1% opted for hormonal treatment, and 14.3% underwent hysterectomy. Ninety percent of the women who did not show improvement in symptoms had FIGO 1 and FIGO 2 fibroids (p=0.002), and 57% had a higher number of cesarean sections (p=0.038). In addition, 61% of these women required a new approach (p<0.001), and 93% opted for treatment after myomectomy (p<0.001). Factors associated with a greater chance of women's symptoms not improving were having more than two cesarean sections (hazard ratio [HR]=3.52, p=0.026), FIGO 1 fibroids (HR=5.75, p=0.003), and FIGO 2-3 fibroids (HR=8.25, p=0.030).
Hysteroscopic myomectomy has a low complication rate, and having fibroids with a larger intramural component is the main factor responsible for myomectomy failure.
本研究旨在评估宫腔镜子宫肌瘤切除术对子宫肌瘤患者症状的疗效。
这是一项回顾性队列研究,对2018年至2023年在一家三级医院接受宫腔镜子宫肌瘤切除术的119例子宫肌瘤患者进行了研究。纳入诊断为黏膜下肌瘤并接受宫腔镜子宫肌瘤切除术的育龄期女性,排除病历中缺乏完成研究所需数据的女性。评估了这些女性的社会人口统计学和临床变量。
这些女性的平均年龄为41.4±6.8岁。在肌瘤中,37.0%为国际妇产科联盟(FIGO)0级,52.5%为FIGO 1级。肌瘤的平均大小为2.7±1.4厘米。并发症发生率为10.0%。子宫肌瘤切除术后,67.2%的女性症状得到改善,66.1%选择了激素治疗,14.3%接受了子宫切除术。症状未改善的女性中,90%患有FIGO 1级和FIGO 2级肌瘤(p=0.002),57%有较高的剖宫产次数(p=0.038)。此外,这些女性中有61%需要新的治疗方法(p<0.001),93%在子宫肌瘤切除术后选择了治疗(p<0.001)。女性症状改善可能性较小的相关因素包括剖宫产次数超过两次(风险比[HR]=3.52,p=0.026)、FIGO 1级肌瘤(HR=5.75,p=0.003)和FIGO 2 - 3级肌瘤(HR=8.25,p=0.030)。
宫腔镜子宫肌瘤切除术并发症发生率低,肌壁内成分较大的肌瘤是子宫肌瘤切除术失败的主要因素。