Andersen K, Waaben J, Husum B, Voldby B, Bødker A, Hansen A J, Gjedde A
J Thorac Cardiovasc Surg. 1985 Oct;90(4):570-9.
The effect of cardiopulmonary bypass on the relationship between brain glucose consumption and regional blood flow is unknown. We measured this relationship in pigs subjected to 3 hours of pulsatile or nonpulsatile cardiopulmonary bypass at normothermia and compared the results to the relationship established in a control group of pigs. A total of 10 regions were sampled in both hemispheres of the porcine brain. In control pigs, cerebral blood flow averaged 46 ml/100 gm and the glucose consumption, 21 mumol/100 gm/min. The ratio between blood flow and glucose consumption was close to 2 ml/mumol in all regions. In pulsatile cardiopulmonary bypass both the whole-brain average and the regional values declined, so that the ratio remained the same, about 2 ml/mumol. In nonpulsatile cardiopulmonary bypass regional blood flow remained normal; the average was 49 ml/100 gm/min, whereas the average glucose consumption declined to 16 mumol/100 gm. In regions with high blood flow rates, the ratio between blood flow and glucose consumption increased to about 3 ml/mumol, indicating perfusion in excess of metabolic demand. We conclude that nonpulsatile cardiopulmonary bypass at normothermia affects the metabolic flow regulation in the brain by interfering with the myogenic contractility of cerebral arterioles.
体外循环对脑葡萄糖消耗与局部血流之间关系的影响尚不清楚。我们在体温正常的猪身上测量了这种关系，这些猪接受了3小时的搏动性或非搏动性体外循环，并将结果与一组对照猪所建立的关系进行比较。在猪脑的两个半球共采集了10个区域的样本。在对照猪中，脑血流量平均为46 ml/100 g，葡萄糖消耗量为21 μmol/100 g/min。所有区域的血流与葡萄糖消耗之比接近2 ml/μmol。在搏动性体外循环中，全脑平均值和局部值均下降，因此该比值保持不变，约为2 ml/μmol。在非搏动性体外循环中，局部血流保持正常；平均值为49 ml/100 g/min，而平均葡萄糖消耗量降至16 μmol/100 g。在血流速率高的区域，血流与葡萄糖消耗之比增加到约3 ml/μmol，表明灌注超过代谢需求。我们得出结论，体温正常时的非搏动性体外循环通过干扰脑动脉的肌源性收缩力来影响脑内的代谢血流调节。
