Stomeo Niccolò, Leuci Laura, Adami Paolo Emilio, Cecconi Maurizio, Carenzo Luca
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Health and Science Department, World Athletics, Monaco; Laboratoire Motricité Humaine Expertise Sport Santé, Université Côte d'Azur, Nice,France; Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.
J Crit Care. 2025 Jun 3;89:155134. doi: 10.1016/j.jcrc.2025.155134.
Exertional heat stroke (EHS) is a life-threatening condition caused by strenuous physical activity, leading to severe hyperthermia and central nervous system dysfunction. Unlike classic heat stroke, EHS can occur in young, healthy individuals and in temperate climates, when heat production exceeds the body's ability to dissipate heat. Rising global temperatures and increased participation in endurance events are contributing to a growing incidence of EHS. Early recognition and rapid cooling are essential to prevent multi-organ failure and death. Whole-body cold-water immersion is the gold standard treatment, and the principle of "cool first, transport second" is key to improving survival. In-hospital care focuses on continued cooling when necessary and managing complications such as acute kidney injury, coagulopathy, liver dysfunction, and neurological impairment. This review provides intensivists with practical guidance on the pathophysiology, diagnosis, and management of EHS. Given their expertise in critical illness and involvement in prehospital and emergency care, intensivists play a pivotal role in early intervention and reducing morbidity and mortality. As EHS incidence rises, increased awareness and preparedness are essential to ensure timely, effective treatment and improve patient outcomes.
劳力性热射病(EHS)是一种由剧烈体力活动引起的危及生命的疾病,可导致严重高热和中枢神经系统功能障碍。与经典热射病不同,EHS可发生在年轻、健康的个体以及温带气候地区,此时产热超过身体散热能力。全球气温上升以及耐力赛事参与人数增加,导致EHS发病率不断上升。早期识别和快速降温对于预防多器官功能衰竭和死亡至关重要。全身冷水浸泡是金标准治疗方法,“先降温,后转运”原则是提高生存率的关键。住院治疗重点在于必要时持续降温以及处理诸如急性肾损伤、凝血病、肝功能障碍和神经功能损害等并发症。本综述为重症医学专家提供了关于EHS病理生理学、诊断和管理的实用指南。鉴于重症医学专家在危重病方面的专业知识以及在院前和急诊护理中的参与,他们在早期干预以及降低发病率和死亡率方面发挥着关键作用。随着EHS发病率上升,提高认识和做好准备对于确保及时、有效治疗以及改善患者预后至关重要。