Patil Hitesh, Khule Siddheshwar Parmeshwar, Gagrani Manish, Pawar Sachin Dattram
Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur 425405, Maharashtra, India.
Department of Microbiology, Department of Basic Medical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Fitoterapia. 2025 Jul;184:106647. doi: 10.1016/j.fitote.2025.106647. Epub 2025 Jun 2.
6-hydroxy Flavone (6-HF) is a naturally occurring biologically active flavonoid found in the leaves of Barleria Prionitis Linn. Plant Family Acanthaceae. The 6-HF exhibits pharmacological activities like non-competitive cytochrome P450 2C9 enzyme inhibitors, potent antioxidants, anti-inflammatory, antimicrobial, and anticancer effects.
This article has been written by collecting detailed information from online databases such as research articles from various public domain sites, PubMed, ScienceDirect, Google Scholar, Web of Science, and Scopus.
A comprehensive review of the available data indicates that 6-HF can modulate key molecular processes involved in tracheal relaxation, inflammation, oxidative stress, and cellular differentiation. 6-HF has a potential anti-inflammatory impact by blocking important inflammatory pathways, a promising anxiolytic and neuroprotective effect by modifying Gamma-Aminobutyric Acid Type A(GABA) receptor function, and a promising anticancer effect by causing apoptosis by activating p53, p21, and caspases. It suppresses the Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway, preventing the activation of pro-inflammatory genes. Also, 6-HF reduces oxidative stress by neutralizing reactive oxygen species (ROS) generated in mitochondria and other cellular organelles. Despite all activities, a detailed study is required to show the exact molecular pathway behind these activities, and investigating its pharmacokinetic characteristics, bioavailability, and potential toxicity will be critical for its development as a medicinal drug. This study aims to provide a comprehensive summary of the pharmacological properties of 6-HF, highlighting the need for further research to determine its therapeutic potential fully.
This review article briefly overviews chemistry, isolation, and pharmacological activity, along with some mechanisms.
6-羟基黄酮（6-HF）是一种天然存在的生物活性黄酮类化合物，存在于刺蕊草科植物刺蕊草的叶子中。6-HF具有多种药理活性，如非竞争性细胞色素P450 2C9酶抑制剂、强效抗氧化剂、抗炎、抗菌和抗癌作用。
本文通过从各种公共领域网站的研究文章、PubMed、ScienceDirect、谷歌学术、科学网和Scopus等在线数据库收集详细信息撰写而成。
对现有数据的全面综述表明，6-HF可以调节参与气管舒张、炎症、氧化应激和细胞分化的关键分子过程。6-HF通过阻断重要的炎症途径具有潜在的抗炎作用，通过改变γ-氨基丁酸A型（GABA）受体功能具有有前景的抗焦虑和神经保护作用，通过激活p53、p21和半胱天冬酶导致细胞凋亡具有有前景的抗癌作用。它抑制活化B细胞的核因子κB（NF-κB）途径，阻止促炎基因的激活。此外，6-HF通过中和线粒体和其他细胞器中产生的活性氧（ROS）来降低氧化应激。尽管有这些活性，但需要进行详细研究以揭示这些活性背后的确切分子途径，并且研究其药代动力学特征、生物利用度和潜在毒性对于其作为药物的开发至关重要。本研究旨在全面总结6-HF的药理特性，强调需要进一步研究以充分确定其治疗潜力。
这篇综述文章简要概述了6-HF的化学、分离、药理活性以及一些作用机制。
