ElNahal Ayat Shaban Mousa, Ibrahim Ali, Abdelhalim Elsayed, Essawy Sally Hassan, Behiry Ahmed, Saadoun Mo'men, Nosair Nahla, Abdelmonsef Hebatallah Abdelmaksoud, Nabeeh Hossam, Abdelbaky Tarek, Taha Diaa-Eldin
Medical Microbiology Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, 33155, Egypt.
Urology Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, 33155, Egypt.
Sci Rep. 2025 Jun 4;15(1):19651. doi: 10.1038/s41598-025-03646-9.
To assess the diagnostic value of serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) in adult patients with Acute Pyelonephritis. A total of 132 participants divided into two groups as 66 Hospitalized patients aged ≥ 20 years suspected of having acute pyelonephritis and 66 age and sex matched participants don't have pyelonephritis. Acute Pyelonephritis was diagnosed in patients with fever, chills or the costovertebral angle tenderness, and bacteriuria higher than 105 CFU/mL without any other focus of infection. No statistically significant differences were observed between the pyelonephritis and non-pyelonephritis groups regarding demographic data or comorbidities. However, the pyelonephritis group exhibited statistically significant differences in Serum NGAL levels, abnormal urine analysis findings, total leukocyte count, and serum C-reactive protein (CRP) levels, with p-values less than 0.001. This study aims to evaluate the potential of Serum NGAL as an early diagnostic biomarker for pyelonephritis, offering a promising tool for timely and accurate diagnosis.
评估血清中性粒细胞明胶酶相关脂质运载蛋白（NGAL）在成年急性肾盂肾炎患者中的诊断价值。共有132名参与者分为两组，66名年龄≥20岁疑似患有急性肾盂肾炎的住院患者，以及66名年龄和性别匹配且无肾盂肾炎的参与者。急性肾盂肾炎的诊断标准为：患者有发热、寒战或肋脊角压痛，且细菌尿高于105 CFU/mL，无任何其他感染病灶。在人口统计学数据或合并症方面，肾盂肾炎组与非肾盂肾炎组之间未观察到统计学显著差异。然而，肾盂肾炎组在血清NGAL水平、尿液分析异常结果、白细胞总数和血清C反应蛋白（CRP）水平方面表现出统计学显著差异，p值小于0.001。本研究旨在评估血清NGAL作为肾盂肾炎早期诊断生物标志物的潜力，为及时准确的诊断提供一种有前景的工具。
