• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一项用于提高重症精神障碍患者依从性的数字药物系统的随机临床试验。

Randomized clinical trial of a digital medication system to enhance adherence in patients with severe mental disorders.

作者信息

Zhou Jia, Zhai Qian, Qi Han, Jin Xiaolei, Xiao Cunli, Li Wenxiu, Song Junwei, Feng Lei, Wang Haibo, Dong Chengcheng, Yu Zibo, Feng Yuan, Wang Gang, Yan Fang

机构信息

Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.

Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.

出版信息

NPJ Digit Med. 2025 Jun 5;8(1):333. doi: 10.1038/s41746-025-01748-2.

DOI:10.1038/s41746-025-01748-2
PMID:40467762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12137551/
Abstract

To evaluate the effectiveness of a digital medication system in improving adherence among patients with serious mental disorders (SMD), we conducted a cluster-randomized controlled trial across 30 communities in Beijing. Participants, aged 18-65 years, were diagnosed with schizophrenia or bipolar disorder and either received intermittent medication or refused treatment. Recruitment occurred from September 2, 2022, to January 12, 2023. The intervention group received a digital medication system. The control group used an online medication diary. The primary outcome was poor adherence, defined as missing 20% or more of prescribed doses at 12 months. Among 216 recruited patients, 206 completed the study. The intervention group showed significantly higher adherence (84/108 vs. 23/108), with an adjusted risk difference of 52.34% (95% CI: 34.65%-70.03%; P < 0.0001). This trial provides the first robust evidence that the digital medication system can significantly improve medication adherence in patients with SMD. Trial Registration: The trial was registered on the Chinese Clinical Trial Registry (chictr.org.cn) on May 29, 2022 (ChiCTR-ICR-2200060359).

摘要

为评估数字药物系统在提高严重精神障碍（SMD）患者服药依从性方面的有效性，我们在北京的30个社区开展了一项整群随机对照试验。参与者年龄在18至65岁之间，被诊断为精神分裂症或双相情感障碍，且要么接受间歇性药物治疗，要么拒绝治疗。招募时间为2022年9月2日至2023年1月12日。干预组使用数字药物系统，对照组使用在线服药日记。主要结局为依从性差，定义为在12个月时漏服20%或更多规定剂量的药物。在招募的216例患者中，206例完成了研究。干预组的依从性显著更高（84/108 vs. 23/108），调整后的风险差异为52.34%（95%CI：34.65%-70.03%；P < 0.0001）。本试验提供了首个有力证据，表明数字药物系统可显著提高严重精神障碍患者的服药依从性。试验注册：该试验于2022年5月29日在中国临床试验注册中心（chictr.org.cn）注册（ChiCTR-ICR-2200060359）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5b7/12137551/c6cd1e51e630/41746_2025_1748_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5b7/12137551/64581af5c6bc/41746_2025_1748_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5b7/12137551/568e20c4cd8c/41746_2025_1748_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5b7/12137551/a95626ecb9a4/41746_2025_1748_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5b7/12137551/c6cd1e51e630/41746_2025_1748_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5b7/12137551/64581af5c6bc/41746_2025_1748_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5b7/12137551/568e20c4cd8c/41746_2025_1748_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5b7/12137551/a95626ecb9a4/41746_2025_1748_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5b7/12137551/c6cd1e51e630/41746_2025_1748_Fig4_HTML.jpg

相似文献

1
Randomized clinical trial of a digital medication system to enhance adherence in patients with severe mental disorders.一项用于提高重症精神障碍患者依从性的数字药物系统的随机临床试验。
NPJ Digit Med. 2025 Jun 5;8(1):333. doi: 10.1038/s41746-025-01748-2.
2
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.在流行地区，服用抗叶酸抗疟药物的人群中，叶酸补充剂与疟疾易感性和严重程度的关系。
Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217.
3
Mobile Texting and Lay Health Supporters to Improve Schizophrenia Care in a Resource-Poor Community in Rural China (LEAN Trial): Randomized Controlled Trial Extended Implementation.移动短信与基层健康助手改善中国农村贫困社区精神分裂症患者的照护（LEAN 试验）：扩展实施的随机对照试验
J Med Internet Res. 2020 Dec 1;22(12):e22631. doi: 10.2196/22631.
4
Lay health supporters aided by mobile text messaging to improve adherence, symptoms, and functioning among people with schizophrenia in a resource-poor community in rural China (LEAN): A randomized controlled trial.在中国农村资源匮乏的社区中，利用手机短信辅助非专业健康支持者提高精神分裂症患者的遵医行为、改善症状和功能（LEAN）：一项随机对照试验。
PLoS Med. 2019 Apr 23;16(4):e1002785. doi: 10.1371/journal.pmed.1002785. eCollection 2019 Apr.
5
Financial incentives to improve adherence to antipsychotic maintenance medication in non-adherent patients: a cluster randomised controlled trial.针对未坚持服用抗精神病维持药物的患者，采用经济激励措施提高其依从性：一项整群随机对照试验。
Health Technol Assess. 2016 Sep;20(70):1-122. doi: 10.3310/hta20700.
6
Development of a Health Behavioral Digital Intervention for Patients With Hypertension Based on an Intelligent Health Promotion System and WeChat: Randomized Controlled Trial.基于智能健康促进系统和微信的高血压患者健康行为数字干预的开发：随机对照试验。
JMIR Mhealth Uhealth. 2024 Apr 5;12:e53006. doi: 10.2196/53006.
7
Digital Solution to Support Medication Adherence and Self-Management in Patients with Cancer (SAMSON): Pilot Randomized Controlled Trial.支持癌症患者药物依从性和自我管理的数字解决方案（SAMSON）：试点随机对照试验
JMIR Form Res. 2025 Feb 19;9:e65302. doi: 10.2196/65302.
8
Advanced Messaging Intervention for Medication Adherence and Clinical Outcomes Among Patients With Cancer: Randomized Controlled Trial.针对癌症患者药物依从性和临床结局的高级信息干预：随机对照试验
JMIR Cancer. 2023 Aug 31;9:e44612. doi: 10.2196/44612.
9
Financial incentives for improving adherence to maintenance treatment in patients with psychotic disorders (Money for Medication): a multicentre, open-label, randomised controlled trial.改善精神病患者维持治疗依从性的经济激励措施（药物治疗资金）：一项多中心、开放标签、随机对照试验
Lancet Psychiatry. 2017 Mar;4(3):199-207. doi: 10.1016/S2215-0366(17)30045-7.
10
Effectiveness of a digital medication event reminder and monitor device for patients with tuberculosis (SELFTB): a multicenter randomized controlled trial.数字药物事件提醒和监测设备对结核病患者的疗效（SELFTB）：一项多中心随机对照试验。
BMC Med. 2022 Sep 28;20(1):310. doi: 10.1186/s12916-022-02521-y.

本文引用的文献

1
Estimating an adjusted risk difference in a cluster randomized trial with individual-level analyses.在个体水平分析的整群随机试验中估计调整后的风险差异。
Stat Methods Med Res. 2025 Jan;34(1):26-44. doi: 10.1177/09622802241293783. Epub 2024 Nov 5.
2
Dissecting the genetic overlap between severe mental disorders and markers of cellular aging: Identification of pleiotropic genes and druggable targets.剖析严重精神障碍与细胞衰老标志物之间的遗传重叠：多效基因和可药物靶点的鉴定。
Neuropsychopharmacology. 2024 May;49(6):1033-1041. doi: 10.1038/s41386-024-01822-5. Epub 2024 Feb 24.
3
Digital health interventions to improve adherence to oral antipsychotics among patients with schizophrenia: a scoping review.
数字健康干预措施改善精神分裂症患者口服抗精神病药物的依从性：范围综述。
BMJ Open. 2023 Nov 17;13(11):e071984. doi: 10.1136/bmjopen-2023-071984.
4
Enhancing Medication Adherence Among Patients With Schizophrenia and Schizoaffective Disorder: Mobile App Intervention Study.提高精神分裂症和分裂情感性障碍患者的药物依从性：移动应用程序干预研究。
SAGE Open Nurs. 2023 Aug 28;9:23779608231197269. doi: 10.1177/23779608231197269. eCollection 2023 Jan-Dec.
5
Age of onset and cumulative risk of mental disorders: a cross-national analysis of population surveys from 29 countries.发病年龄与精神障碍的累积风险：29 个国家人口调查的跨国分析。
Lancet Psychiatry. 2023 Sep;10(9):668-681. doi: 10.1016/S2215-0366(23)00193-1. Epub 2023 Jul 30.
6
Why does non-adherence to treatment remain a leading cause of relapse in patients with bipolar disorder?为什么不坚持治疗仍是双相情感障碍患者复发的主要原因？
Eur Neuropsychopharmacol. 2023 Aug;73:16-18. doi: 10.1016/j.euroneuro.2023.04.012. Epub 2023 Apr 27.
7
Resin Infiltration of Non-Cavitated Proximal Caries Lesions in Primary and Permanent Teeth: A Systematic Review and Scenario Analysis of Randomized Controlled Trials.乳牙和恒牙非龋性邻面龋损的树脂浸润：随机对照试验的系统评价和情景分析
J Clin Med. 2023 Jan 16;12(2):727. doi: 10.3390/jcm12020727.
8
A Digital Intervention Using Daily Financial Incentives to Increase Medication Adherence in Severe Mental Illness: Single-Arm Longitudinal Pilot Study.一项使用每日经济激励措施提高严重精神疾病患者药物依从性的数字干预：单臂纵向试点研究。
JMIR Ment Health. 2022 Oct 12;9(10):e37184. doi: 10.2196/37184.
9
Residual Effect of Texting to Promote Medication Adherence for Villagers with Schizophrenia in China: 18-Month Follow-up Survey After the Randomized Controlled Trial Discontinuation.中国农村精神分裂症患者短信促进药物依从性的残留效果：随机对照试验停止后 18 个月的随访调查。
JMIR Mhealth Uhealth. 2022 Apr 19;10(4):e33628. doi: 10.2196/33628.
10
Are caregivers ready for digital? Caregiver preferences for health technology tools to monitor medication adherence among patients with serious mental illness.照护者是否做好了迎接数字化的准备？严重精神疾病患者的照护者对用于监测药物依从性的健康技术工具的偏好。
Digit Health. 2022 Mar 10;8:20552076221084472. doi: 10.1177/20552076221084472. eCollection 2022 Jan-Dec.