Yan Zheng, Yao Ying, Xu Qin, He Xin, Zhou Xinyu, Wang Hairui
Chengdu Research Base of Giant Panda Breeding, Chengdu, China.
Sichuan Key Laboratory of Conservation Biology for Endangered Wildlife, Chengdu, China.
Commun Biol. 2025 Jun 5;8(1):864. doi: 10.1038/s42003-025-08270-x.
The impact of dietary microorganisms on host microbiota is recognized, but the underlying mechanisms remain unclear. This study examined the effects of bamboo surface microbiota, including virulence factors, antibiotic resistance genes (ARGs), and mobile genetic elements from different bamboo parts (leaves, shoots, and culms), on giant panda gut microbiota using three pairs of twins. Results showed that bamboo and fecal samples shared 1670 microbial species, with shoot surface microbiota contributing the highest proportion (21%, Bayesian source tracking) of contemporaneous gut microbiota, primarily by increasing abundances of Escherichia coli and ARGs. Klebsiella pneumoniae and Salmonella enterica also showed high co-occurrence in both bamboo and fecal samples, indicating potential colonization. Additionally, Streptococcus suis, Acinetobacter, and Mycobacterium progressively declined in fecal samples as bamboo shoot intake increased, suggesting these microbes are likely transient. The findings emphasize the impact of foodborne microorganisms on the host and the importance of conservation management.
饮食中的微生物对宿主微生物群的影响已得到认可，但其潜在机制仍不清楚。本研究利用三对双胞胎研究了竹子表面微生物群，包括来自不同竹部位（叶、笋和茎）的毒力因子、抗生素抗性基因（ARG）和移动遗传元件，对大熊猫肠道微生物群的影响。结果表明，竹子和粪便样本共有1670种微生物，笋表面微生物群对同期肠道微生物群的贡献比例最高（21%，贝叶斯溯源），主要是通过增加大肠杆菌和ARG的丰度。肺炎克雷伯菌和肠炎沙门氏菌在竹子和粪便样本中也有很高的共现率，表明存在潜在的定植。此外，随着竹笋摄入量的增加，粪便样本中的猪链球菌、不动杆菌和分枝杆菌逐渐减少，表明这些微生物可能是短暂存在的。这些发现强调了食源微生物对宿主的影响以及保护管理的重要性。
