Yanofsky Russell, Jogendran Rohit, Hoxha Tedi, Pathak Avani, Orchanian-Cheff Ani, Chhibba Tarun, Sasson Alexa N, Tandon Parul
Division of Gastroenterology and Hepatology, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Department of Internal Medicine, University of Toronto, Toronto, Ontario, Canada.
Inflamm Bowel Dis. 2025 Jun 4. doi: 10.1093/ibd/izaf095.
The association between inflammatory bowel disease (IBD) and eosinophilic esophagitis (EoE) remains unclear. We aimed to perform a systematic review and meta-analysis on the association between EoE, IBD, and other immune-mediated inflammatory diseases.
A systematic literature search was conducted in Ovid MEDLINE, Ovid Embase, and the Cochrane Central Register of Controlled Trials (Ovid) from inception to July 2023. The primary outcome was to compare the frequency of an EoE diagnosis in IBD and other immune-mediated inflammatory disease processes versus control populations. Where pooled analysis was possible, we reported odds ratios (ORs) with 95% confidence intervals (CIs). I2 values were used to report heterogeneity, with values >50% suggesting substantial heterogeneity.
We identified 2612 eligible studies, of which 38 studies were included. A diagnosis of EoE was significantly greater in patients with IBD compared to the general population (OR 3.9; 95% CI, 2.6-5.9 [I2 = 99.5%]). There was no significant increase in EoE in patients with ulcerative colitis compared to Crohn's disease (OR 1.0; 95% CI, 0.7-1.3 [I2 = 88.7%]). EoE was also significantly increased in patients with atopic dermatitis (OR 2.4; 95% CI, 1.9-3.1 3 [I2 = 70.4%]) compared to those without atopic dermatitis.
Both IBD and atopic dermatitis were associated with an increased odds of EoE diagnosis. Further research is needed to determine the underlying mechanisms behind these potential associations.
炎症性肠病（IBD）与嗜酸性食管炎（EoE）之间的关联尚不清楚。我们旨在对EoE、IBD和其他免疫介导的炎症性疾病之间的关联进行系统评价和荟萃分析。
在Ovid MEDLINE、Ovid Embase和Cochrane对照试验中央注册库（Ovid）中进行了一项系统的文献检索，检索时间从数据库建立至2023年7月。主要结局是比较IBD和其他免疫介导的炎症性疾病过程中EoE诊断的频率与对照人群。在可能进行汇总分析的情况下，我们报告了具有95%置信区间（CI）的比值比（OR）。I²值用于报告异质性，I²值>50%表明存在实质性异质性。
我们识别出2612项符合条件的研究，其中38项研究被纳入。与普通人群相比，IBD患者中EoE的诊断率显著更高（OR 3.9；95%CI，2.6 - 5.9 [I² = 99.5%]）。与克罗恩病患者相比，溃疡性结肠炎患者中EoE的诊断率没有显著增加（OR 1.0；95%CI，0.7 - 1.3 [I² = 88.7%]）。与无特应性皮炎的患者相比，特应性皮炎患者中EoE的诊断率也显著增加（OR 2.4；95%CI，1.9 - 3.1 [I² = 70.4%]）。
IBD和特应性皮炎均与EoE诊断几率增加相关。需要进一步研究以确定这些潜在关联背后的潜在机制。
