Gao Lei, Mao Rui, Zeng Jie, Wen Lin
Department of Medical Equipment, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Department of Cardiology, Structure Heart Disease Center, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Front Cardiovasc Med. 2025 May 21;12:1436789. doi: 10.3389/fcvm.2025.1436789. eCollection 2025.
This meta-analysis aimed to evaluate the efficacy and safety of J-valve in patients with Aortic regurgitation (AR).
PubMed, Embase, the Cochrane Library, and Web of Science databases were searched from inception to November 2024. Primary outcome included Procedural Success, and secondary outcome included In-Hospital Mortality, 30-Day Mortality, One-Year All-Cause Mortality, Stroke Incidence and Complications. The risk of bias was assessed by subgroup analysis, sensitivity analysis, and publication bias, including funnel plot, Egger's test, and Begg's test.
A total of 9 studies involving 552 patients were included in this meta-analysis. The results indicated a surgical success rate of 96% (95% CI: 0.94-0.99). The in-hospital mortality rate was 3% (95% CI: 0.01-0.04), the 30-day mortality rate was 3% (95% CI: 0.01-0.05), and the 1-year all-cause mortality rate was 6% (95% CI: 0.04-0.08). Additionally, the incidence of stroke was 2% (95% CI: 0.01-0.03), and the incidence of other complications was 22% (95% CI: 0.16-0.28).
This meta-analysis indicates that the J-Valve prosthesis exhibits favorable short-term efficacy in patients with severe aortic regurgitation (AR); however, a significant incidence of complications persists. A thorough risk assessment is crucial when determining the appropriate treatment strategy. Furthermore, postoperative follow-up duration should be extended to monitor patient outcomes effectively.
https://www.crd.york.ac.uk/PROSPERO/view/CRD42024552406, identifier CRD42024552406.
本荟萃分析旨在评估J-Valve治疗主动脉瓣关闭不全（AR）患者的疗效和安全性。
检索了从数据库建立至2024年11月的PubMed、Embase、Cochrane图书馆和Web of Science数据库。主要结局包括手术成功，次要结局包括住院死亡率、30天死亡率、1年全因死亡率、卒中发生率和并发症。通过亚组分析、敏感性分析和发表偏倚评估偏倚风险，包括漏斗图、Egger检验和Begg检验。
本荟萃分析共纳入9项研究，涉及552例患者。结果显示手术成功率为96%（95%CI：0.94-0.99）。住院死亡率为3%（95%CI：0.01-0.04），30天死亡率为3%（95%CI：0.01-0.05），1年全因死亡率为6%（95%CI：0.04-0.08）。此外，卒中发生率为2%（95%CI：0.01-0.03），其他并发症发生率为22%（95%CI：0.16-0.28）。
本荟萃分析表明，J-Valve人工瓣膜在重度主动脉瓣关闭不全（AR）患者中显示出良好的短期疗效；然而，并发症发生率仍然较高。在确定合适的治疗策略时，进行全面的风险评估至关重要。此外，应延长术后随访时间以有效监测患者预后。
https://www.crd.york.ac.uk/PROSPERO/view/CRD42024552406，标识符CRD42024552406。
