Jah Fungwe, Mejias Asuncion, Nzirawa Tendai, Silveira Rita C, Berger Angelika, Travan Laura, Kinoshita Daisuke, Ishak Shareena, Çelik Tolga, Al-Dandan Faisal, Mahr Benedikt, Masters Christine
Medical Affairs, BioPharmaceuticals Medical, AstraZeneca, Hamburg, Germany.
Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, United States.
Front Pediatr. 2025 May 21;13:1590842. doi: 10.3389/fped.2025.1590842. eCollection 2025.
Respiratory syncytial virus (RSV) is the leading cause of hospitalization for bronchiolitis in infants worldwide, and age (<6 months) and underlying comorbidities (e.g., prematurity, congenital heart disease) are risk factors for severe disease. However, some centers face challenges in identifying and implementing preventative measures, and best practices, for the care of at-risk infants. Therefore, this study aimed to identify best practice examples in RSV care for neonatal and pediatric populations in leading centers globally, and to understand how these practices can be widely implemented. Following a literature review, multidisciplinary teams were interviewed in 10 centers globally (1 center per country; 40 interviews conducted between May and November 2023). Centers were included based on pre-determined criteria (e.g., type of center, services provided, focus on RSV research) to ensure a representative view of RSV care. The identified best practice interventions were critically reviewed by a group of RSV experts [healthcare professionals (HCPs) and a patient group representative] and assessed for their impact on patient care and transferability to other centers. Fifty-seven unique best practice interventions were identified, sixteen of which were prioritized, across five best practice themes: (1). Caregiver education and engagement: Provision of timely caregiver education on RSV infection and care. (2). HCP education: Provision of continuous evidence-based HCP education. (3). HCP-led RSV prophylaxis services: Additional support services to ensure at-risk infants are protected ahead of the RSV season. (4). Protocols and ways of working: Establishing evidence-based procedures to ensure best practices are followed within clinical practice. (5). Technology and innovation: Leveraging digital services to optimize care delivery and experience. This study identified interventions that may improve patient outcomes and quality of care for RSV disease in the pediatric and neonatal populations. The next steps will be to disseminate and implement best practice examples across healthcare systems and care settings globally.
呼吸道合胞病毒（RSV）是全球范围内导致婴儿毛细支气管炎住院的主要原因，年龄（<6个月）和潜在合并症（如早产、先天性心脏病）是重症疾病的危险因素。然而，一些中心在识别和实施针对高危婴儿护理的预防措施及最佳实践方面面临挑战。因此，本研究旨在确定全球主要中心针对新生儿和儿科人群的RSV护理最佳实践案例，并了解如何广泛实施这些实践。在进行文献综述后，对全球10个中心的多学科团队进行了访谈（每个国家1个中心；2023年5月至11月期间进行了40次访谈）。根据预先确定的标准（如中心类型、提供的服务、对RSV研究的关注）纳入中心，以确保对RSV护理有代表性的观点。一组RSV专家[医疗保健专业人员（HCPs）和患者群体代表]对确定的最佳实践干预措施进行了严格审查，并评估了它们对患者护理的影响以及向其他中心的可转移性。共确定了57项独特的最佳实践干预措施，其中16项被列为优先措施，涵盖五个最佳实践主题：（1）. 护理人员教育与参与：及时为护理人员提供关于RSV感染和护理的教育。（2）. HCP教育：提供持续的循证HCP教育。（3）. HCP主导的RSV预防服务：提供额外的支持服务，以确保高危婴儿在RSV季节之前得到保护。（4）. 协议和工作方式：建立循证程序，以确保临床实践中遵循最佳实践。（5）. 技术与创新：利用数字服务优化护理提供和体验。本研究确定了可能改善儿科和新生儿人群RSV疾病患者结局和护理质量的干预措施。下一步将是在全球医疗系统和护理环境中传播和实施最佳实践案例。
