Bao Xinxin, Wang Qiuhong, Geng Haiying, Yuan Xiaohua
Xinxin Bao Department of Clinical Laboratory, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Qiuhong Wang Department of Clinical Laboratory, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Pak J Med Sci. 2025 May;41(5):1305-1310. doi: 10.12669/pjms.41.5.10448.
To explore the correlation of interleukin 6 (IL-6) and procalcitonin (PCT) with severity of (MPP) in children and their prognostic value.
One hundred twenty children with MPP and 100 healthy children who underwent physical examination at the Clinical Laboratory Department of Nantong University Maternal and Child Health Hospital from November 2023 to December 2023 were selected as the study subjects, and were divided into the experimental group and the control group. The experimental group was divided into mild MPP group (n=70 ) and severe MPP group (n=50 ) according to the severity of the disease. According to the condition after one course of treatment, separated MPP children into good prognosis group (n=96) and poor prognosis group (n=24). The IL-6 and PCT levels of the experimental/control group before treatment and the good/bad prognosis group after treatment were compared, respectively. The lung function of children with MPP before and after treatment was also examined, and the changes of respiratory rate (RR), tidal volume (VT), expiratory time (Te), peak time (TPTEF), and peak volume (VPTEF) were observed. The correlation between pulmonary function and IL-6, PCT in MPP children was analyzed by Pearson analysis. Receiver operation curve was adopted to analyze the predictive value of IL-6, PCT for poor prognosis.
IL-6 and PCT were increased in the severe MPP group compared to the mild MPP group (P<0.001) and tended to decrease in the good prognosis group compared to the poor prognosis group (P<0.001). Fifty-nine of the 70 cases in the good prognosis group were patients with mild MPP, suggesting that patients with mild MPP have a better prognosis. The results of respiratory function showed an increase in RR (P<0.001) and a decrease in VT (P=0.007), TPTEF/Te (P<0.001), VPTEF/VT (P<0.001) in the severe MPP group compared to the mild MPP group. The results of correlation analysis revealed that IL-6, PCT were negatively correlated with VT, TPTEF/Te and VPTEF/VT (P<0.001). ROC curve analysis revealed that IL-6 and PCT co-diagnosis had a better predictive ability for poor prognosis in children with MPP (AUC=0.843).
IL-6 and PCT are positively related to the severity of MPP, the combined detection of IL-6 and PCT has certain clinical usefulness to evaluate and assess prognosis of MPP children.
探讨白细胞介素6（IL-6）和降钙素原（PCT）与儿童支原体肺炎（MPP）严重程度的相关性及其预后价值。
选取2023年11月至2023年12月在南通大学附属医院检验科进行体检的120例MPP患儿和100例健康儿童作为研究对象，分为实验组和对照组。实验组根据病情严重程度分为轻症MPP组（n = 70）和重症MPP组（n = 50）。根据一个疗程治疗后的情况，将MPP患儿分为预后良好组（n = 96）和预后不良组（n = 24）。分别比较实验组/对照组治疗前以及预后良好/不良组治疗后的IL-6和PCT水平。同时检测MPP患儿治疗前后的肺功能，观察呼吸频率（RR）、潮气量（VT）、呼气时间（Te）、呼气峰时间（TPTEF）和呼气峰容积（VPTEF）的变化。采用Pearson分析MPP患儿肺功能与IL-6、PCT的相关性。采用受试者工作特征曲线分析IL-6、PCT对预后不良的预测价值。
重症MPP组IL-6和PCT水平高于轻症MPP组（P < 0.001），预后良好组较预后不良组呈下降趋势（P < 0.001）。预后良好组70例中有59例为轻症MPP患者，提示轻症MPP患者预后较好。呼吸功能结果显示，重症MPP组RR升高（P < 0.001），VT降低（P = 0.007），TPTEF/Te降低（P < 0.001），VPTEF/VT降低（P < 0.001）。相关性分析结果显示，IL-6、PCT与VT、TPTEF/Te和VPTEF/VT呈负相关（P < 0.001）。ROC曲线分析显示，IL-6和PCT联合诊断对MPP患儿预后不良具有较好的预测能力（AUC = 0.843）。
IL-6和PCT与MPP严重程度呈正相关，联合检测IL-6和PCT对评估MPP患儿预后具有一定临床价值。
