Elizondo-Ramirez Javier, Gutierrez-Licona Efrain Roberto, Unzueta-Villalobos Katya Elizabeth, Del Rio-Martinez Christopher J, Ordonez-Solorio Luis Alberto, Munoz-Cobos Arturo
Department of Neurosurgery, NeuroteamCUU (Neurosurgical Team of Chihuahua), Chihuahua, Mexico.
Research Coordination Department, School of Medicine, University of Durango, Chihuahua Campus, Chihuahua, Mexico.
Surg Neurol Int. 2025 May 30;16:212. doi: 10.25259/SNI_202_2025. eCollection 2025.
Cranial neuralgias are characterized by sharp lancinating pain that occurs on specific regions served by cranial nerves. Glossopharyngeal neuralgia (GPN) and trigeminal neuralgia (TN) are disorders for which etiology, epidemiology, and pain regions differ. On the other hand, the treatment stays the same as microvascular decompression, which serves as a safe approach for these entities.
We performed a specific search strategy using the following Boolean terms: (Combined hyperactive dysfunction syndrome) OR ("Trigeminal" AND "Glossopharyngeal" AND "neuralgia") AND ("Concomitant" OR "Combined" OR "Simultaneous" OR "Concurrent" OR "at once" OR synchronously"). Including PubMed and Scopus, we found 73 results, of which 10 were included in the study. Furthermore, we did a manual search for one relevant study. The studies were included only if cases with concomitant TN and GPN were present.
Fifteen cases were retrieved. The mean age of presentation was 66. About 53.3% of cases were left-sided; the most common etiology was posterior inferior cerebellar artery compression (73.3%). Microvascular decompression is this pathology's most popular management approach (73.3%). Only two cases reported complications (13.3%).
The concomitant appearance of TN and GPN is scarce. The microvascular decompression persists as the most popular approach. There are a few treatment modalities used apart from surgical decompression. More research on these areas should be done to generate interest in their application.
颅神经痛的特点是在颅神经所支配的特定区域出现尖锐的刺痛。舌咽神经痛（GPN）和三叉神经痛（TN）是病因、流行病学和疼痛区域不同的疾病。另一方面，治疗方法相同，均为微血管减压术，这是治疗这些疾病的一种安全方法。
我们使用以下布尔术语执行了特定的搜索策略：（联合多动功能障碍综合征）或（“三叉神经”且“舌咽神经”且“神经痛”）且（“伴随”或“联合”或“同时”或“并发”或“一次”或“同步”）。通过检索包括PubMed和Scopus在内的数据库，我们找到了73条结果，其中10条被纳入研究。此外，我们手动搜索了一项相关研究。仅纳入伴有TN和GPN的病例。
共检索到15例病例。出现症状时的平均年龄为66岁。约53.3%的病例为左侧发病；最常见的病因是小脑后下动脉压迫（73.3%）。微血管减压术是这种疾病最常用的治疗方法（73.3%）。只有两例报告了并发症（13.3%）。
TN和GPN同时出现的情况很少见。微血管减压术仍然是最常用的方法。除了手术减压外，还有一些其他治疗方式。应该对这些领域进行更多研究，以激发人们对其应用的兴趣。
