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本文引用的文献

1
Renal Cell Carcinoma Metastasis to the Left Atrium.左心房肾细胞癌转移。
Tex Heart Inst J. 2022 May 1;49(3). doi: 10.14503/THIJ-20-7452.
2
Determinants of renal cell carcinoma invasion and metastatic competence.肾细胞癌侵袭和转移能力的决定因素。
Nat Commun. 2021 Oct 4;12(1):5760. doi: 10.1038/s41467-021-25918-4.
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Cardiac Biventricular Metastasis From Renal Cell Carcinoma.肾细胞癌的心脏双心室转移
Cureus. 2020 Oct 9;12(10):e10870. doi: 10.7759/cureus.10870.
4
Cardiac tumors prevalence and mortality: A systematic review and meta-analysis.心脏肿瘤的患病率和死亡率:系统评价和荟萃分析。
Int J Surg. 2020 Apr;76:178-189. doi: 10.1016/j.ijsu.2020.02.039. Epub 2020 Mar 10.
5
Renal Cell Carcinoma: Diagnosis and Management.肾细胞癌:诊断与管理。
Am Fam Physician. 2019 Feb 1;99(3):179-184.
6
The Clinical Presentation, Survival Outcomes, and Management of Patients With Renal Cell Carcinoma and Cardiac Metastasis Without Inferior Vena Cava Involvement: Results From a Pooled Clinical Trial Database and Systematic Review of Reported Cases.肾细胞癌伴心脏转移而无下腔静脉受累患者的临床表现、生存结局和治疗:来自汇总临床试验数据库的结果和已报告病例的系统评价。
Clin Genitourin Cancer. 2018 Apr;16(2):e327-e333. doi: 10.1016/j.clgc.2017.11.005. Epub 2017 Dec 6.
7
Kidney Cancer, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.肾癌,2017 年第 2 版,NCCN 肿瘤学临床实践指南。
J Natl Compr Canc Netw. 2017 Jun;15(6):804-834. doi: 10.6004/jnccn.2017.0100.
8
Left ventricular metastasis from renal cell carcinoma causing left ventricular outflow tract obstruction.左心室转移来自肾细胞癌导致左心室流出道梗阻。
Korean Circ J. 2010 Aug;40(8):410-3. doi: 10.4070/kcj.2010.40.8.410. Epub 2010 Aug 31.
9
Cardiac metastasis from a renal cell carcinoma.肾细胞癌的心脏转移
Can J Cardiol. 2006 Dec;22(14):1231-2. doi: 10.1016/s0828-282x(06)70964-3.
10
Primary and secondary neoplasms of the heart.心脏的原发性和继发性肿瘤。
Am J Cardiol. 1997 Sep 1;80(5):671-82. doi: 10.1016/s0002-9149(97)00587-0.

肾细胞癌伴心脏转移及右心近乎闭塞:一例报告

Renal cell carcinoma with cardiac metastasis and near right heart obliteration: A case report.

作者信息

Downing Maren, Quinn Kristen M, Odle Micheal

机构信息

Campbell University School of Osteopathic Medicine, Lillington, NC, USA.

Department of Surgery, Medical University of South Carolina, Charleston, SC, USA.

出版信息

J Cardiol Cases. 2025 Jan 30;31(4):117-120. doi: 10.1016/j.jccase.2025.01.004. eCollection 2025 Apr.

DOI:10.1016/j.jccase.2025.01.004
PMID:40469423
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12130822/
Abstract

UNLABELLED

Renal cell carcinoma (RCC) is the most common type of primary kidney cancer with up to 30 % of patients having metastatic disease at the time of diagnosis. Metastasis to the heart is extremely rare with only a few cases ever reported. Most patients with cardiac metastases of any origin do not develop symptoms of cardiac dysfunction. The classic triad of presentation for RCC is hematuria, flank pain, and a palpable mass. We report a rare occurrence of cardiac involvement of RCC infiltrating both the right atrium and right ventricle in an otherwise healthy female patient whose presenting symptom was dyspnea. Dyspnea, although a vague presenting symptom with a large differential diagnosis, is the most common presenting symptom of cardiac tumors and a sudden presentation of dyspnea in a patient with RCC should encourage the consideration of cardiac metastasis. The importance of repeat imaging and cross-disciplinary care in a patient with RCC with cardiac involvement is well displayed. A delay in cancer diagnosis may lead to delay in therapy and the result may be associated with significant morbidity and mortality. Quick action including evaluation and treatment for RCC is imperative to increase the chance for survival.

LEARNING OBJECTIVE

Metastasis to the heart is extremely rare and most patients do not develop cardiac symptoms. Dyspnea is a vague presenting symptom requiring a broad differential to determine underlying pathology. Here, acute dyspnea in a patient with renal cell carcinoma was the presenting symptom of cardiac metastasis and continued repeat imaging in this patient with supplemental oxygen requirements showed fast spread into the right heart.

摘要

未标注

肾细胞癌(RCC)是原发性肾癌最常见的类型,高达30%的患者在诊断时已有转移性疾病。心脏转移极为罕见,仅有少数病例报道。大多数任何来源的心脏转移患者都不会出现心脏功能障碍症状。RCC的典型三联征表现为血尿、胁腹痛和可触及肿块。我们报告了一例罕见的RCC心脏受累病例,累及一名原本健康的女性患者的右心房和右心室,其主要症状为呼吸困难。呼吸困难虽是一种鉴别诊断范围广的模糊主要症状,但却是心脏肿瘤最常见的主要症状,RCC患者突然出现呼吸困难应促使考虑心脏转移。RCC合并心脏受累患者重复成像和跨学科护理的重要性得到了充分体现。癌症诊断延迟可能导致治疗延迟,结果可能与显著的发病率和死亡率相关。迅速采取行动,包括对RCC进行评估和治疗,对于增加生存机会至关重要。

学习目标

心脏转移极为罕见,大多数患者不会出现心脏症状。呼吸困难是一种模糊的主要症状,需要广泛鉴别以确定潜在病理。在此,一名肾细胞癌患者的急性呼吸困难是心脏转移的主要症状,对该需要补充氧气的患者持续进行重复成像显示肿瘤迅速扩散至右心。