Chen-Carrington Annie, Goodreau Adam, Strife Brian J, Shinn Laurie, Rhodes Jennifer
Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Commonwealth Dermatology, Richmond, Virginia.
Eplasty. 2025 Jan 21;25:e2. eCollection 2025.
Verrucous venous malformation (VVM) is a rare, congenital, low-flow vascular anomaly composed of capillaries and veins in the dermis and subcutaneous tissues. Diagnosis is difficult because knowledge of cases is rare and typically identified with sonographic imaging and elevated GLUT-1. Treatment is mired by high rates of recurrence and residual pain, with further enlargement upon resection or injury. Current management strategies include a combination of laser therapy, surgery, cryotherapy, and topical steroids, each with varying rates of success.
The authors examine a case of confirmed VVM, which was initially treated with a candela pulsed dye laser and propranolol to no avail. A combination of surgical approaches were chosen.
We now look to topical sirolimus 1% as an adjunct for this patient with residual lesions. Questions remain as to the effectiveness, optimal dose, and duration of topical sirolimus and whether this combination of surgical and topical intervention will be effective in the treatment for VVM.
疣状静脉畸形（VVM）是一种罕见的先天性低流量血管异常，由真皮和皮下组织中的毛细血管和静脉组成。由于病例少见，诊断困难，通常通过超声成像和GLUT-1升高来确诊。治疗因复发率高、残留疼痛以及切除或损伤后进一步增大而陷入困境。目前的管理策略包括激光治疗、手术、冷冻治疗和外用类固醇的联合应用，每种方法的成功率各不相同。
作者检查了一例确诊的VVM病例，该病例最初用坎德拉脉冲染料激光和普萘洛尔治疗无效。选择了多种手术方法联合治疗。
我们现在考虑将1%的外用西罗莫司作为该残留病变患者的辅助治疗。关于外用西罗莫司的有效性、最佳剂量和持续时间，以及这种手术和外用干预的联合治疗对VVM是否有效，仍存在疑问。
