Fitch Angela
knownwell, Needham, MA.
Mayo Clin Proc Innov Qual Outcomes. 2025 May 8;9(3):100621. doi: 10.1016/j.mayocpiqo.2025.100621. eCollection 2025 Jun.
The worldwide prevalence of obesity more than doubled between 1990 and 2022 (men, 4.8%-14.0%; women, 8.8%-18.5%), with similar trends observed for obesity-related diseases, including type 2 diabetes mellitus. Despite this increase in prevalence, many individuals with obesity remain untreated. There are several barriers limiting access to effective care, including the stigma and bias associated with obesity and lack of insurance coverage as a standard job benefit. Additionally, unrealistic expectations for rate of weight-loss and the weight-loss process as well as a lack of proper education on the weight-loss journey and treatment options can contribute to the inability to achieve weight-loss goals and a reluctance to try evidence-based approaches. Therefore, there is a need for effective management and education focusing on individualized treatment and setting viable expectations for the treatment of patients with obesity. Health care providers should compassionately discuss with their patients the importance of weight-loss, the long-term clinical benefits, and expectations for the weight-loss journey, including amount and timing of weight-loss, as well as the potential financial implications associated with obesity treatment. Health care providers should also be able to inform patients along the treatment journey, including about potential adverse events and how they can be managed. Importantly, treatments and decisions should be tailored to each patient using shared decision making with a focus on their characteristics, history, and goals. In this study, the expectations and current use of approved antiobesity medications in the United States are reviewed.
1990年至2022年间,全球肥胖患病率增加了一倍多(男性从4.8%增至14.0%;女性从8.8%增至18.5%),与肥胖相关的疾病(包括2型糖尿病)也呈现出类似趋势。尽管患病率有所上升,但许多肥胖患者仍未得到治疗。有几个障碍限制了人们获得有效治疗,包括与肥胖相关的耻辱感和偏见,以及缺乏作为标准工作福利的保险覆盖。此外,对减肥速度和减肥过程的不切实际期望,以及在减肥过程和治疗选择方面缺乏适当教育,可能导致无法实现减肥目标,以及不愿尝试循证方法。因此,需要进行有效的管理和教育,重点是个性化治疗,并为肥胖患者的治疗设定可行的期望。医疗保健提供者应与患者富有同情心地讨论减肥的重要性、长期临床益处,以及对减肥过程的期望,包括减肥的数量和时间,以及与肥胖治疗相关的潜在经济影响。医疗保健提供者还应在治疗过程中向患者提供信息,包括潜在的不良事件以及如何处理这些事件。重要的是,应采用共同决策的方式,根据每个患者的特征、病史和目标,为其量身定制治疗方法和决策。在本研究中,对美国已批准的抗肥胖药物的期望和当前使用情况进行了综述。