Wang QiaoLing, Liu JiaYu, Hu ShengLin, Du JunWu, Zhou ShuZhi, Huang ZhengLin, Liu Yanwu, Yang Kongjie, Zhang Ling, Yang Jian, Yuan Qing
Hepatobiliary Surgery, Yaan People's Hospital, Ya'an, China.
Oncology Surgery, Yaan People's Hospital, Ya'an, China.
Front Med (Lausanne). 2025 May 21;12:1586778. doi: 10.3389/fmed.2025.1586778. eCollection 2025.
A detailed reference range for complete blood count of healthy adults in the Western Sichuan Plateau region is unavailable. This study aimed to explore changes in complete blood count (CBC) in healthy adults across high-altitude regions of Ganzi Prefecture, Sichuan Province, to establish altitude-specific reference intervals and improve diagnostic accuracy and provide tailored clinical guidance for residents in these areas.
CBC data from 3,485 healthy individuals from four altitudes-Guza (1,400 m), Lucheng (2,500 m), Luhuo (3,200 m), and Litang (4,100 m)-were collected between January 2022 and December 2023. The data were analyzed by sex, altitude, age groups, and their interactions to establish reference intervals.
CBC indicators showed significant changes with increasing altitude. Red blood cell (RBC) count, hemoglobin (HGB), hematocrit (HCT), white blood cell (WBC) count, and platelet (PLT) count all significantly increased as altitude rose ( < 0.05). Males had significantly higher RBC, WBC, and PLT counts than females across all altitudes ( < 0.05), except in Litang, where HCT and HGB differences between sexes were not significant ( < 0.05). With increasing age, RBC count, HCT, HGB, WBC count, and PLT count increased in both sexes. Most CBC indicators in the study population exceeded national reference intervals, except for HGB and HCT in males from Guza and Lucheng.
This study established CBC reference intervals for the high-altitude regions of Ganzi Prefecture, revealing significant variations by altitude, sex, and age. These findings provide valuable insights for improving disease diagnosis and medical care for high-altitude residents.
川西高原地区缺乏健康成年人全血细胞计数的详细参考范围。本研究旨在探讨四川省甘孜州高海拔地区健康成年人全血细胞计数（CBC）的变化，建立特定海拔的参考区间，提高诊断准确性，并为这些地区的居民提供针对性的临床指导。
收集了2022年1月至2023年12月期间来自四个海拔高度——姑咱（1400米）、泸定（2500米）、炉霍（3200米）和理塘（4100米）——的3485名健康个体的CBC数据。对数据按性别、海拔、年龄组及其相互作用进行分析，以建立参考区间。
随着海拔升高，CBC指标显示出显著变化。红细胞（RBC）计数、血红蛋白（HGB）、血细胞比容（HCT）、白细胞（WBC）计数和血小板（PLT）计数均随着海拔升高而显著增加（<0.05）。在所有海拔地区，男性的RBC、WBC和PLT计数均显著高于女性（<0.05），但在理塘，男女之间的HCT和HGB差异不显著（<0.05）。随着年龄增长，男女的RBC计数、HCT、HGB、WBC计数和PLT计数均增加。研究人群中的大多数CBC指标超过了国家参考区间，姑咱和泸定男性的HGB和HCT除外。
本研究建立了甘孜州高海拔地区的CBC参考区间，揭示了海拔、性别和年龄的显著差异。这些发现为改善高海拔地区居民的疾病诊断和医疗保健提供了有价值的见解。
