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利用基线支气管活检DNA甲基化预测慢性阻塞性肺疾病患者对皮质类固醇的反应

Predicting corticosteroid response in COPD using baseline bronchial biopsy DNA methylation.

作者信息

Gillett Tessa E, Brandsma Corry-Anke, Faiz Alen, Timens Wim, Koppelman Gerard H, Nawijn Martijn C, van den Berge Maarten

机构信息

Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

出版信息

ERJ Open Res. 2025 Jun 2;11(3). doi: 10.1183/23120541.00724-2024. eCollection 2025 May.

DOI:10.1183/23120541.00724-2024
PMID:40470150
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12134920/
Abstract

https://bit.ly/4eKOC5t.

摘要

https://bit.ly/4eKOC5t. (此为链接,无法准确翻译其内容,保留原文形式)

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ece/12134920/187a5b36ba3d/00724-2024.01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ece/12134920/187a5b36ba3d/00724-2024.01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ece/12134920/187a5b36ba3d/00724-2024.01.jpg

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本文引用的文献

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Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary.全球慢性阻塞性肺疾病倡议 2023 年报告:GOLD 执行摘要。
Eur Respir J. 2023 Apr 1;61(4). doi: 10.1183/13993003.00239-2023. Print 2023 Apr.
2
Nasal DNA methylation at three CpG sites predicts childhood allergic disease.三个 CpG 位点的鼻腔 DNA 甲基化可预测儿童过敏性疾病。
Nat Commun. 2022 Dec 1;13(1):7415. doi: 10.1038/s41467-022-35088-6.
3
Immunophenotyping of Acute Inflammatory Exacerbations of Lung Injury Driven by Mutant Surfactant Protein-C: A Role for Inflammatory Eosinophils.
由突变表面活性蛋白C驱动的肺损伤急性炎症加重的免疫表型分析:炎症性嗜酸性粒细胞的作用
Front Pharmacol. 2022 Apr 27;13:875887. doi: 10.3389/fphar.2022.875887. eCollection 2022.
4
Genes coding for transcription factors involved in stem cell maintenance are repressed by TGF-β and downstream of Slug/Snail2 in COPD bronchial epithelial progenitors.基因编码参与干细胞维持的转录因子被 TGF-β 抑制,并在 COPD 支气管上皮祖细胞中被 Slug/Snail2 下游抑制。
Mol Biol Rep. 2021 Oct;48(10):6729-6738. doi: 10.1007/s11033-021-06664-8. Epub 2021 Aug 26.
5
Eosinophilic inflammation in COPD: from an inflammatory marker to a treatable trait.COPD 中的嗜酸性粒细胞炎症:从炎症标志物到可治疗的特征。
Thorax. 2021 Feb;76(2):188-195. doi: 10.1136/thoraxjnl-2020-215167. Epub 2020 Oct 29.
6
Predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD.嗜酸粒细胞和中性粒细胞对 COPD 患者 ICS 临床疗效的预测价值。
Respirology. 2018 Nov;23(11):1023-1031. doi: 10.1111/resp.13312. Epub 2018 Apr 26.
7
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